DLG4, discs large MAGUK scaffold protein 4, 1742

N. diseases: 91; N. variants: 54
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE A significant deficit of transforming growth factor-β1 (TGF-β1), paralleling memory deficits and depressive-like phenotype, was found in the hippocampus of Aβ-injected mice in combination with a significant reduction of the synaptic proteins synaptophysin and PSD-95. 31293421 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE We found that CUMS induced depressive-like behaviors including decreased sucrose preference ratio, prolonged immobility and reduced locomotor and exploratory activity; cognitive deficits including spatial learning and memory impairment; reduced dendritic spine density and number of branches; thinned postsynaptic density; downregulated SIRT1/microRNA-134 pathway, decreased BDNF and synaptic proteins including synaptophysin (SYN) and postsynaptic density protein 95 (PSD95) expression in the hippocampus. 30716615 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Deletion of the Rps23rg1 gene resulted in severe memory deficits and impairment of postsynaptic structure and function, with marked reductions in postsynaptic densities-93 and -95 (PSD-93 and PSD-95) levels. 30292394 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Behavioral tests revealed that EGb761 rescued HHcy-induced spatial reference memory deficit and upregulated the expression of synapse-associated protein PSD95 and synapsin-1. 28847282 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE We found that the oral pretreatment of glycyrrhizin inhibited HMGB1 cytosolic expression, increased the PSD-95 protein expression, and attenuated the severity of postoperative memory impairment, as indicated by the shorter swimming latency and distance in MWM trials when compared with the mice subjected to the surgery alone. 29034441 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Results showed that hypertonic saline effectively alleviated spatial learning and memory deficit, enhanced synaptic plasticity of CA3-CA1 hippocampal synapses, upregulated N-methyl-d-aspartate receptor subunit 2B (NR2B) and postsynaptic density protein 95 (PSD-95) surface expressions, reduced oxidative stress and increased Nissl bodies in 2VO model rats. 28934194 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Intriguingly, transduction of the artificial transcription factor PSD95-VP64 rescued memory deficits in aged and Alzheimer's disease mice. 29155979 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 PosttranslationalModification phenotype BEFREE Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI. 28522733 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Inhibition of the interaction between PSD95 and nNOS ameliorated DA-induced memory impairment. 28932186 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE The study provides preclinical evidence that Fasudil treatment ameliorated memory deficits in APP/PS1 Tg mice, accompanied by the reduction of Aβ deposition and Tau protein phosphorylation, the decrease of BACE and the increase of PSD-95, as well as inhibition of TLRs-NF-κB-MyD88 inflammatory cytokine axis. 27401064 2017