DOK1, docking protein 1, 1796

N. diseases: 45; N. variants: 1
Disease: Leukemogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 Biomarker disease BEFREE Originally identified in chronic myelogenous leukemia cells as a highly phosphorylated substrate for the chimeric p210(bcr-abl) protein, DOK1 was suspected to play a role in leukemogenesis. 16823827 2006
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 Biomarker disease BEFREE This is the first example of a Dok1 mutation in B-CLL and the data suggest that Dok1 might play a role in leukemogenesis. 14730347 2004
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 Biomarker disease BEFREE These data indicate that p62(dok) acts as a negative regulator of growth factor-induced cell proliferation, at least in part through downregulating Ras/MAPK signaling pathway, and that p62(dok) can oppose leukemogenesis by p210(bcr-abl). 11489947 2001