DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Concordance between TS and DPD expression in primary and metastatic tumours was low. 16012177 2005
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Fresh-frozen samples of metastases were obtained from 58 previously untreated patients with ACRC. mRNA expression of TS and DPD was quantified using an RT-PCR assay. 16251201 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 Biomarker phenotype CTD_human DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. 17611699 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Stepwise multiple linear regression models showed a significant association of DPD expression with distant metastases (P = 0.004) and residual tumor categories (P = 0.03). 19180589 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE The data show that DPD mRNA expression correlated significantly with Lauren type while TS mRNA expression correlated with distant metastasis. 25388847 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Our previous study showed that administering oxaliplatin as first-line chemotherapy increased ERCC1 and DPD levels in liver colorectal cancers (CRCs) metastases. 26372896 2015