DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Concordance between TS and DPD expression in primary and metastatic tumours was low. 16012177 2005
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 Biomarker phenotype CTD_human DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. 17611699 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Fresh-frozen samples of metastases were obtained from 58 previously untreated patients with ACRC. mRNA expression of TS and DPD was quantified using an RT-PCR assay. 16251201 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Our previous study showed that administering oxaliplatin as first-line chemotherapy increased ERCC1 and DPD levels in liver colorectal cancers (CRCs) metastases. 26372896 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE Stepwise multiple linear regression models showed a significant association of DPD expression with distant metastases (P = 0.004) and residual tumor categories (P = 0.03). 19180589 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 AlteredExpression phenotype BEFREE The data show that DPD mRNA expression correlated significantly with Lauren type while TS mRNA expression correlated with distant metastasis. 25388847 2015