Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRD2 Taq I and 5-HTTVNTR polymorphisms had statistically significant effects on PTSD, while 5-HTTLPR did not.
|
30983408 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An OXTR-DRD2 interaction (rs2268498 × rs1801028) was identified to confer risk of provisional PTSD diagnosis (OR = 9.18, 95% CI = 3.07-27.46 and P = 7.37e-05) and further subset analysis indicated that rs2268498 genotypes controlled the association directions of rs1801028 and rs1801028 genotypes also controlled the association directions of rs2268498.
|
31848444 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.
|
31291235 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Results:</b> Statistical genetics analysis identified a <i>DRD2/ANNK1</i>-<i>COMT</i> interaction (rs1800497 × rs6269), which is associated with PTSD diagnosis (<i>P</i><sub>interaction</sub> = 0.0008055 and <i>P</i><sub>corrected</sub> = 0.0169155).
|
29760667 |
2018 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further analyses revealed that this patient subset had high rates of post-traumatic stress disorder (PTSD), and enrichment in several distinct genetic polymorphisms associated with cellular responses to stress and DNA damage (PARP1), and in striatal dopamine processing (ANKK1, COMT, DRD2).
|
28257413 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that rs1800497 in DRD2 and the VNTR in SLC6A3 showed significant association with PTSD.
|
26986136 |
2016 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the association of polymorphisms within the entire DRD2 gene with PTSD in a case-control study.
|
26363619 |
2015 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dopamine receptor D2 (DRD2) and serotonin transporter (5-HTT) genes are associated with posttraumatic stress disorder (PTSD).
|
26002549 |
2015 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a functional DRD2 promoter polymorphism (rs12364283) to be most highly associated with PTSD liability [odds ratio (OR) 1.65 (1.27-2.15); P = 1.58 × 10(-4) ]; however, this association was not significant, with a stringent Bonferroni correction for multiple comparisons.
|
23647975 |
2014 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population.
|
23103549 |
2013 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither the DRD2 nor the DAT polymorphisms explained the variation seen in PTSD diagnosis, total PTSD symptom severity, and categories B and C symptom severities.
|
20554017 |
2010 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.
|
18833581 |
2009 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRD2 variants are associated with severe co-morbid psychopathology in PTSD subjects.
|
16632165 |
2006 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRD2 A1 allele may prove to be a useful marker to assist clinicians in predicting which patients with PTSD are likely to obtain improvements in social functioning with paroxetine treatment.
|
12957328 |
2003 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRD2 A1 allele was associated with PTSD.
|
12217937 |
2002 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although less intensively studied than substance use disorders, the DRD2 gene has been implicated in Tourette's syndrome (TS), post-traumatic stress disorder (PTSD) and certain symptoms associated with affective disorders and schizophrenia.
|
11256581 |
2000 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that DRD2 alleles are not associated with PTSD in this sample, and that genetic variation at the DRD2 locus is not likely to be an important contributor to risk for this disorder.
|
10088049 |
1999 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that a DRD2 variant in linkage disequilibrium with the D2A1 allele confers an increased risk to PTSD, and the absence of the variant confers a relative resistance to PTSD.
|
8874837 |
1996 |