|
Addictive Behavior
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Particularly important is the expression decline of DRD2 given its physiological implication in obesity and addiction.
|
31682820 |
2020 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study provides preliminary evidence that DRD2 dopamine receptor gene SNPs are associated with indoor tanning addiction and young women with variant genotypes and elevated depressive symptoms may be at higher risk.
|
31185074 |
2020 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
No influence of DRD2 and DRD4 variants was observed in men regarding addiction severity.
|
30367264 |
2019 |
|
Addictive Behavior
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
The findings regarding an association with alcohol craving and tobacco consumption point towards a crucial role of DRD2-gene methylation in the neurobiology of addictive behavior.
|
31530416 |
2019 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.
|
30104163 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore, clinically approved dopamine D2 receptor antagonists may be useful in the treatment of methamphetamine addiction.
|
29501686 |
2018 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We suggest that the relatively better memory for rewarded stimuli in carriers of low-expressing <i>DRD2</i> variants may reflect an intermediate phenotype of addiction memory.
|
28507526 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Positron emission tomography (PET) imaging consistently shows blunted striatal dopamine release and decreased dopamine D2 receptor availability in addiction.
|
27987559 |
2017 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Connect function from IPA My Pathway toolbox showed that DRD2 is the gene common to both the list of genetic variations associated with all three addiction phenotypes and the components of the brain neuronal signaling network involved in substance addiction.
|
26044620 |
2015 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A DRD2 7-SNPs haplotype that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S/D2L splicing, was indicated in both addictions.
|
25875614 |
2015 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Considering new evidence supporting the association of DRD2 and its adjacent gene ankyrin repeat and kinase domain containing 1 (ANKK1) with various addictions, in this paper, we provide an updated view of the involvement of variants in DRD2 and ANKK1 in the etiology of nicotine dependence (ND) and alcohol dependence (AD) based on linkage, association, and molecular studies.
|
25139281 |
2015 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We hypothesize that dopamine D2 receptor (DRD2) gene Taq1 A2 allele is associated with a subtype of non-SUD schizophrenics and as such may act as a putative protective agent against the development of addiction to alcohol or other drugs of abuse.
|
24636783 |
2014 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In addition, dopamine D2 receptor (DRD2) gene may also interact with the dopamine metabolizing genes and link to addiction.
|
23266708 |
2013 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction.
|
23683269 |
2013 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Further, they hypothesize that the polymorphism of dopamine D2 receptor increases the susceptibility to and severity of addiction.
|
21613340 |
2012 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The TaqI A single-nucleotide polymorphism (SNP) in the DRD2 gene and the 3' variable number tandem repeat (VNTR) polymorphism in the DAT1 gene have been implicated in psychiatric disorders and drug addictions.
|
20170711 |
2010 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Polymorphisms of DRD2 and ANKK1 have been associated with psychiatric syndromes where there is believed to be an underlying learning process deficit such as addiction, post-traumatic stress disorder and psychopathy.
|
19900188 |
2010 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
TaqIA, the most widely analyzed genetic polymorphism in addictions, has traditionally been considered a gene marker for association with D2 dopamine receptor gene (DRD2).
|
19853839 |
2010 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The importance of dopamine D2 receptors (DRD2) for central nervous dopaminergic signalling makes variants in the DRD2 gene potential modulators of the risk or course of various behavioural, psychiatric or neurologic diseases (e.g. addiction, schizophrenia, Parkinson's disease).
|
19512960 |
2009 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Animal and human studies of addiction indicate that the D2 dopamine receptor (DRD2) plays a critical role in the mechanism of drug reward.
|
17948902 |
2008 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, carriers of dopamine receptor type 2 (DRD2)-TaqI A1 have been hypothesized to be potentially vulnerable to addictive behaviors.
|
18555060 |
2008 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported.
|
17394052 |
2007 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Dopamine D2 receptor reduction seems to decrease sensitivity to negative action consequences, which may explain an increased risk of developing addictive behaviors in A1-allele carriers.
|
18063800 |
2007 |
|
Addictive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The A1 allele of the dopamine D2 receptor gene (DRD2) is associated with a reduced number of dopamine binding sites in the brain and with the increased likelihood of substance abuse and addictive behavior.
|
15492764 |
2005 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The DRD(2) has been one of the most widely studied in neuropsychiatric disorders in general, and in alcoholism and other addictions in particular.
|
15457501 |
2005 |