DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Disease: Alcohol or Other Drugs use ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.050 GeneticVariation disease BEFREE Gene-based analyses found significant associations with genes implicated in the neurobiology of substance use (DRD2, PDE4B). 28937693 2017
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.050 Biomarker disease BEFREE It is also possible that DRD2 is related to a behavioral phenotype common to externalizing disorders and substance use. 19344737 2009
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.050 GeneticVariation disease BEFREE The results provide support for the DRD2 A1 allele as a marker identifying a subgroup of COAs at high risk for developing substance use problems. 16102380 2005
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.050 GeneticVariation disease BEFREE In the present study, five diallelic sites spanning the DRD2 gene were determined in combined Caucasian (non-Hispanic) studies of more severe alcoholics (n = 92) and controls screened for substance use (n = 85). 11054769 2000
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.050 GeneticVariation disease BEFREE In conclusion, the severity of alcohol dependence in alcoholics and of substance use behaviors in controls are important variables in DRD2 allelic association. 7695792 1994