DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease HPO
CUI: C1860861
Disease: TREMOR, HEREDITARY ESSENTIAL, 1
TREMOR, HEREDITARY ESSENTIAL, 1 		0.300 Biomarker disease CTD_human
CUI: C0011253
Disease: Delusions
Delusions 		0.120 Biomarker disease HPO
CUI: C0013362
Disease: Dysarthria
Dysarthria 		0.100 Biomarker disease HPO
CUI: C0018524
Disease: Hallucinations
Hallucinations 		0.100 Biomarker disease HPO
CUI: C0027562
Disease: Negativism
Negativism 		0.100 Biomarker phenotype HPO
CUI: C0234378
Disease: Static Tremor
Static Tremor 		0.100 Biomarker phenotype HPO
CUI: C0239842
Disease: Tremor of hands
Tremor of hands 		0.100 Biomarker phenotype HPO
CUI: C1866986
Disease: Social and occupational deterioration
Social and occupational deterioration 		0.100 Biomarker phenotype HPO
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. 1362221 1992
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia? 8135304 1993
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE A study of the association between schizophrenia and the dopamine D3 receptor gene. 8225313 1993
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The present study does not provide evidence that the BalI polymorphism in the dopamine D3 receptor gene is involved in the pathophysiology of schizophrenia. 8517175 1993
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We conclude that the genetic predisposition to schizophrenia in these pedigrees is not due to a mutation in the DRD3 locus. 8464957 1993
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 Biomarker disease BEFREE Linkage of bipolar disorder and recurrent depression to the DRD3 gene was tested using a series of autosomal dominant and recessive models with varying penetrance levels. 8509522 1993
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.370 GeneticVariation disease BEFREE Pairwise linkage analyses were carried out between the D3 dopamine receptor gene locus (DRD3) and schizophrenia (including major depression among its pleiotropic manifestations). 8464957 1993
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE Pairwise linkage analyses were carried out between the D3 dopamine receptor gene locus (DRD3) and schizophrenia (including major depression among its pleiotropic manifestations). 8464957 1993
CUI: C0221480
Disease: Recurrent depression
Recurrent depression 		0.300 Biomarker disease PSYGENET Linkage of bipolar disorder and recurrent depression to the DRD3 gene was tested using a series of autosomal dominant and recessive models with varying penetrance levels. 8509522 1993
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.070 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.070 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		0.070 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993