DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		0.070 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		0.070 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		0.070 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C2700438
Disease: MAJOR AFFECTIVE DISORDER 7
MAJOR AFFECTIVE DISORDER 7 		0.060 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C2700438
Disease: MAJOR AFFECTIVE DISORDER 7
MAJOR AFFECTIVE DISORDER 7 		0.060 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C2700439
Disease: MAJOR AFFECTIVE DISORDER 8
MAJOR AFFECTIVE DISORDER 8 		0.060 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C2700439
Disease: MAJOR AFFECTIVE DISORDER 8
MAJOR AFFECTIVE DISORDER 8 		0.060 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C2700440
Disease: MAJOR AFFECTIVE DISORDER 9
MAJOR AFFECTIVE DISORDER 9 		0.060 Biomarker disease BEFREE The dopamine D3 receptor gene: no association with bipolar affective disorder. 8098068 1993
CUI: C2700440
Disease: MAJOR AFFECTIVE DISORDER 9
MAJOR AFFECTIVE DISORDER 9 		0.060 GeneticVariation disease BEFREE Thus, this substitution, which is the first sequence variation identified in the dopamine D3 receptor gene altering the amino acid sequence of the protein, can be regarded as a protein variant with no major effect on the susceptibility to bipolar affective disorder. 8493294 1993
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The finding of contrasting results regarding an association between schizophrenia and the MscI polymorphism site in the dopamine D3 receptor gene prompted us to study the distribution of this polymorphism in an Italian sample of 52 patients suffering from delusional disorder, 85 schizophrenic patients and 78 control subjects. 7914142 1994
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE The hypothesis that the DRD3 gene has a predisposing role in schizophrenia was not supported by these population and family studies. 7903510 1994
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. 7909989 1994
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We have carried out a linkage study between the susceptibility gene for schizophrenia and polymorphism of the dopamine D3 receptor gene in two Japanese pedigrees. 7810586 1994
CUI: C0040517
Disease: Gilles de la Tourette syndrome
Gilles de la Tourette syndrome 		0.330 GeneticVariation disease BEFREE Controversial results possibly suggesting an association between Tourette's Syndrome (TS) and excess of homozygosity at a Msc I polymorphism in the Dopamine D3 receptor (DRD3) gene have recently been reported. 7810583 1994
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker group PSYGENET For DRD3 this is the first exclusion of affective disorder from this locus in the 3q13.3 where DRD3 has been localized. 7972571 1994
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker group BEFREE For DRD3 this is the first exclusion of affective disorder from this locus in the 3q13.3 where DRD3 has been localized. 7972571 1994
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.030 GeneticVariation disease BEFREE Thus this mutation in the coding sequence of the DRD3 gene is unlikely to confer susceptibility to OCD. 7810583 1994
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Association study of dopamine D3 receptor gene and schizophrenia. 8825896 1995
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Our results suggest that, at least in our well-defined population, the candidate genes DRD3 and DRD4 do not appear to play a major role in the genetic etiology of schizophrenia. 7860086 1995
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches. 8775753 1995
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 GeneticVariation disease BEFREE Despite the fact that more information could have been considered and that association studies provide limited information, there is good evidence that this DRD3 polymorphism does not play a major role in the genetic component of alcoholism. 8825889 1995
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C0011206
Disease: Delirium
Delirium 		0.320 Biomarker disease PSYGENET Without correction for multiple testing, we found a significantly increased allele frequency of a common DRD3 gene variant expressing a serine at position 9 in the extracellular N-terminal part of the receptor protein in 55 alcohol-dependent individuals with delirium (chi 2 = 4.1, df = 1, p = 0.042). 8750359 1995
CUI: C0011206
Disease: Delirium
Delirium 		0.320 GeneticVariation disease BEFREE Without correction for multiple testing, we found a significantly increased allele frequency of a common DRD3 gene variant expressing a serine at position 9 in the extracellular N-terminal part of the receptor protein in 55 alcohol-dependent individuals with delirium (chi 2 = 4.1, df = 1, p = 0.042). 8750359 1995
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995