Given that there are sex differences in pain perception, there may be differences in responses to nociceptive stimuli between male and female D3RKO mice.
We performed genotyping for catechol-O-methyltransferase (COMT) Val158Met (rs4680) and dopamine D3 receptor (DRD3) rs6280" genes_norm="1814">Ser9Gly (rs6280) polymorphisms, which were analyzed for associations with pain phenotypes.
We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients.
We also demonstrate our technique using the transmission/disequilibrium test (TDT) to check for linkage between schizophrenia and a locus related to the D(3) dopamine receptor, and on a hypnosis pain management data set.