DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease PSYGENET DRD4 gene may play an important role in psychotic symptomatology rather than in unique diagnosis, BD, for example. 25233244 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease PSYGENET In the sample with bipolar disorder, we observed significant association between DRD4 7R-genotype and AAO (n=274, β=-.148, p=.012). 22543114 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE In the sample with bipolar disorder, we observed significant association between DRD4 7R-genotype and AAO (n=274, β=-.148, p=.012). 22543114 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease PSYGENET The review of association studies gave interesting results, as a number of genes seem to be definitively involved in BP, such as SLC6A4, TPH2, DRD4, SLC6A3, DAOA, DTNBP1, NRG1, DISC1 and BDNF. 18332878 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease PSYGENET In our sample of 814 patients comprising 114 with schizophrenia, 416 with bipolar affective disorder and 284 with unipolar affective disorder, we studied interactions between the tryptophan hydroxylase (TPH), the serotonin transporter (5-HTTLPR), and the dopamine receptor (DRD4) genes in relation to five major psychiatric symptomatology scores. 15627807 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease PSYGENET DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager. 15860340 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager. 15860340 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease LHGDN Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder. 12232779 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE DRD4 exon 3 variants are not a main factor influencing TSD outcome in bipolar disorder. 10646829 1999
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE We have performed a case-control analysis of dopamine D2-like receptor (DRD2, DRD3 and DRD4) gene polymorphisms in 118 Han Chinese cases with bipolar affective disorder and 196 control subjects, and replication analysis in 157 English cases and 143 control subjects. 10482338 1999
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 Biomarker disease BEFREE Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study. 9129719 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE However, both observations were not replicated; we therefore conclude that variations in this repeat at the DRD4 gene do not contribute to the genetic component of manic depression. 7810585 1994
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.380 GeneticVariation disease BEFREE We have begun our search for an autosomal linkage to bipolar affective disorder in the Old Order Amish (OOA110) with the 48 bp coding region polymorphism for DRD4. 7914460 1994