JAG1, jagged canonical Notch ligand 1, 182

N. diseases: 420; N. variants: 63
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 AlteredExpression disease BEFREE This co-culture induced an increase of Notch receptors expression on OCC surface and an increase of Jagged 1 expression on E4<sup>+</sup>ECs surface and activation of survival pathways leading to chemoresistance by E4<sup>+</sup>ECs. 31182109 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 Biomarker disease BEFREE The purpose of the present study was to investigate the roles of Jagged1 in the platinum resistance of ovarian cancer and its possible mechanisms. 30993885 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 Biomarker disease BEFREE Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. 21753153 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 AlteredExpression disease BEFREE High levels of Jagged-1 are a common feature of ovarian tumors. 21042738 2010
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 Biomarker disease LHGDN Taken together, our results show that Jagged-1 is the primary Notch3 ligand in ovarian carcinoma and Jagged-1/Notch3 interaction constitutes a juxtacrine loop promoting proliferation and dissemination of ovarian cancer cells within the intraperitoneal cavity. 18632624 2008