Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether such reduction in immunogenicity is sufficient to protect β cells from autoimmunity upon transplantation, we transplanted fish Ins2 transgenic (expressing solely Seriola dumerili Ins2), NOD, or B16:A-dKO islets under the kidney capsules of 5 weeks old female NOD wildtype mice.
|
30899071 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we used direct non-invasive confocal imaging of islets transplanted in the anterior chamber of the eye (ACE) to investigate the anti-islet autoimmunity in NOD mice before, during and after diabetes onset.
|
31087105 |
2019 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because thyroid autoimmunity develops slowly (over months), NOD.H2<sup>h4</sup> mice are usually exposed to excess dietary iodide to accelerate and amplify the process.
|
30566234 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Dendritic cell (DC) immunotherapy has been effective for prevention of type 1 diabetes (T1D) in NOD mice but fails to protect if initiated after active autoimmunity.
|
29651443 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice.
|
29415894 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The pathological role of MyD88-dependent innate immune signaling in autoimmune diseases including AS has been studied using mouse models, such as NOD mice.
|
30250175 |
2018 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we eliminate clinical biliary disease by backcrossing this <i>Pkhd1</i> mutation onto the C57BL/6 genetic background; thus, the NOD genetic background (which promotes autoimmunity) is essential for disease.
|
29158418 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, NOD, a highly autoimmunity-prone mouse strain, exhibits more profound GALT-related immune response upon immunization compared to the strains that are less prone to autoimmunity.
|
28851631 |
2017 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, therapeutic intervention in NOD mice through nutritional supplementation or lentivirus-mediated expression of an ω-3 fatty acid desaturase, mfat-1, normalized blood glucose and insulin levels for at least 182 days, blocked the development of autoimmunity, prevented lymphocyte infiltration into regenerated islets, and sharply elevated the expression of the β cell markers pancreatic and duodenal homeobox 1 (Pdx1) and paired box 4 (Pax4).
|
28375156 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-γ(-/-) NOD.H-2h4 mice develop autoimmune disease with extensive hyperplasia and proliferation of thyroid epithelial cells (TEC H/P) and fibrosis.
|
27173733 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
MCs of diabetic NOD mice are overly inflammatory and secrete large amounts of IL-6 that favors differentiation of IL-17-secreting T cells at the site of autoimmunity.
|
26732858 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
AAV8mIP-IL35 vaccination of NOD mice at a late preclinical stage of type 1 diabetes (T1D) suppressed β-cell autoimmunity and prevented diabetes onset.
|
27859048 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We could show that the genetic predisposition provided by the NOD background was essential for creating a fertile field for the development of liver-specific autoimmunity.
|
23475565 |
2013 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutations in inflammasome-related proteins, particularly in NOD-like receptor (NLR) genes, have been strongly associated to the occurrence of AIDs, whereas the link between inflammasome and ADs is less clear.
|
22878274 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In the current study, we used a gene therapy-based approach to assess the efficacy of recombinant adeno-associated virus vectors expressing inducible IL-2 or TGF-β1 transgenes to suppress ongoing β cell autoimmunity in NOD mice.
|
21317396 |
2011 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We generated transgenic mice lacking endogenous class II molecules, HLA-DR3.Abo and HLA-DQ8.Abo transgenic mice in NOD and HLA-DQ8.Abo in B10 background, to study the role of MHC in spontaneous autoimmunity.
|
19811893 |
2010 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether development contributes to autoimmunity, we compared four target organs in NOD mice (an animal model for type 1 diabetes and Sjogren's syndrome) with NOD-SCID mice (which lack lymphocytes) and normal controls.
|
18301381 |
2008 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We generated HLA-DR3.Abetao and HLA-DQ8.Abetao transgenic mice in NOD and HLA-DQ8.Abetao in B10 background to study spontaneous autoimmunity.
|
17499268 |
2007 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
HLA-DQ8 transgenic IAb knockout NOD mice (NOD.DQ8/Ab(0); DQA1*0301, DQB1*0302) develop spontaneous anticardiomyocyte autoimmunity with pathology very similar to human IDCM, but why the heart is targeted is unknown.
|
16751419 |
2006 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Three of these four genes colocalize with NOD mouse diabetes susceptibility genes--the strongest concordance identified to date between any two autoimmune diseases--reflecting the association between autoimmune diabetes and type 1 gastritis in humans.
|
15763989 |
2005 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The highly multigenic background on which diabetes develops in the NOD mouse and in the human suggests that numerous gene variants associate in contributing to activation of autoimmunity to beta-cells.
|
16306346 |
2005 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in humans and candidate genes in the NOD mouse has made significant progress in recent years.
|
16257508 |
2005 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The autoimmune disease type 1 diabetes in humans and NOD mice is determined by multiple genetic factors, among the strongest of which is the inheritance of diabetes-permissive MHC class II alleles associated with susceptibility to disease.
|
15467836 |
2004 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The addition of DQ8 contributes sensitivity to gliadin, and the addition of the NOD background contributes to autoimmunity and pathogenesis.
|
15489956 |
2004 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We induced anti-GBM disease in DBA/1, C57BL/6, AKR, and NOD mice with recombinant human alpha3(IV)NC1 to investigate the involvement of humoral and cellular autoimmunity.
|
12724345 |
2003 |