|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, the younger sister with PV developed PF with only anti-Dsg1 antibody detected.
|
21352303 |
2011 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Naringenin also down-regulated the expression of Dsg1, Dsg3 and E-cadherin compared with the PV group.
|
28591691 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3.
|
28661086 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, we tested agreement between BIOCHIP-Dsg1 and ELISA-Dsg1 in differentiation pemphigus vulgaris subtypes.
|
30910537 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS).
|
22810308 |
2012 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease caused by IgG autoantibodies that target Dsg1 and Dsg3 in pemphigus foliaceus and pemphigus vulgaris respectively.
|
20178466 |
2009 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two Dsg are targeted by pathogenic autoantibodies produced in the course of autoimmune bullous skin diseases, Dsg1 in pemphigus foliaceus (PF), and Dsg3 and Dsg1 in pemphigus vulgaris.
|
17056584 |
2006 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mucosal blister-producing PV variant is characterized by autoantibodies against desmoglein (Dsg)3, whereas mucosal and skin lesion-producing PV is characterized by autoantibodies to Dsg3 and Dsg1.
|
17442983 |
2007 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
PV-IgG1, 2 and 4 were found to react mainly with Dsg3 and PV-IgG3 mainly with Dsg1 and 3.
|
10951142 |
2000 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide evidence that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were equally effective in causing epidermal splitting in human skin and keratinocyte dissociation in vitro.
|
17640963 |
2007 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the completely stratified keratinocytes cultured on collagen membrane, Dsg1 became predominant, with subsequent reduction of PV antigen expression.
|
7547386 |
1995 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is a potentially fatal blistering disease characterized by autoantibodies against cell surface adhesion proteins desmoglein (Dsg) 3 and Dsg1.
|
17392832 |
2007 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively.
|
10551416 |
1999 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in which autoantibodies bind, respectively, to desmoglein 3 and desmoglein 1, are strongly associated with HLA-class II DR4 and DR14 alleles.
|
12604316 |
2003 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though, the use of saliva anti-DSG3 and anti-DSG1 ELISA for the diagnosis of PV has been already reported, there are no studies concerning the utilization of saliva by the BIOCHIP approach.
|
28064226 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We used three PV-IgG fractions from different patients containing high or low levels of anti-Dsg1 and anti-Dsg3 antibodies, and the presence or not of anti-desmocollin (Dsc) antibodies, using a passive transfer mouse model of PV.
|
31370093 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice.
|
11120754 |
2000 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between pemphigus vulgaris and eosinophilic esophagitis in this case, although previously unreported, is explicable on the basis of dysregulation of desmoglein 1 (DSG1).
|
28297154 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
These Ag-specific ELISAs revealed that more than one-half of PV sera (26 of 49) had anti-Dsg1 Abs in addition to anti-Dsg3 Abs.
|
9257868 |
1997 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is a rare blistering skin disorder characterized by the disadhesion of keratinocytes due to autoantibody attack against epidermal targets including desmoglein (Dsg) 3, Dsg 1 and possibly other adhesion and non-adhesion molecules.
|
26911801 |
2016 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization.
|
8034325 |
1994 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that both pemphigus foliaceus and pemphigus vulgaris sera react with conformationally sensitive epitopes in the amino-terminal region of Dsg1.
|
7543545 |
1995 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation.
|
28211055 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem.
|
18838249 |
2008 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against Dsg 3 and/or Dsg 1 could be detected in 71 (100%) of 71 PV sera and against Dsg 1 in 48 (96%) of 50 PF sera.
|
20163452 |
2010 |