|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, we tested agreement between BIOCHIP-Dsg1 and ELISA-Dsg1 in differentiation pemphigus vulgaris subtypes.
|
30910537 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We used three PV-IgG fractions from different patients containing high or low levels of anti-Dsg1 and anti-Dsg3 antibodies, and the presence or not of anti-desmocollin (Dsc) antibodies, using a passive transfer mouse model of PV.
|
31370093 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is a rare blistering disease caused by IgG autoantibodies against the epidermal adhesion molecules desmoglein (Dsg)3 and Dsg1 providing a well-characterized paradigm of an antibody-mediated organ-specific autoimmune disease.
|
31258541 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune blistering disease driven by pathogenic antibodies to desmoglein-1 and -3, levels of which correlate with disease activity.
|
31192484 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, anti-Dsg1/3 AuAb-free PV can be a model for elucidating the roles of non-Dsg antigen-specific AuAbs in the physiological regulation of keratinocyte cell-cell adhesion and blister development.
|
30692201 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, in human epidermis PV-IgG-induced skin blistering and ultrastructural alterations of desmosomes were not affected by Src inhibition, indicating that Src may not be critical for skin blistering in intact human skin, at least when high levels of autoantibodies targeting Dsg1 are present.
|
31024527 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF) patients present autoantibodies against Dsg1.
|
31178865 |
2019 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes.
|
29132070 |
2018 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cells share lineages with IgG1, IgA1, and IgA2.
|
30157430 |
2018 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Naringenin also down-regulated the expression of Dsg1, Dsg3 and E-cadherin compared with the PV group.
|
28591691 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3.
|
28661086 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though, the use of saliva anti-DSG3 and anti-DSG1 ELISA for the diagnosis of PV has been already reported, there are no studies concerning the utilization of saliva by the BIOCHIP approach.
|
28064226 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between pemphigus vulgaris and eosinophilic esophagitis in this case, although previously unreported, is explicable on the basis of dysregulation of desmoglein 1 (DSG1).
|
28297154 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation.
|
28211055 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals.
|
28012821 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study was conducted to assess the relationship between salivary and serum Dsg1 and Dsg3 levels, and whether salivary Dsg1 and Dsg3 levels correlate with clinical disease severity of oral mucosal lesions in PV.
|
28543318 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This case illustrates the potential key role and clinical benefit of tracking anti-Dsg1 levels to monitor and conceivably predict disease activity in patients with PV.<em>J Drugs Dermatol.2017;16(2):135-139.</em>.
|
28300855 |
2017 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is a rare blistering skin disorder characterized by the disadhesion of keratinocytes due to autoantibody attack against epidermal targets including desmoglein (Dsg) 3, Dsg 1 and possibly other adhesion and non-adhesion molecules.
|
26911801 |
2016 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1.
|
26597100 |
2016 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS).
|
22810308 |
2012 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion.
|
22996451 |
2012 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, the younger sister with PV developed PF with only anti-Dsg1 antibody detected.
|
21352303 |
2011 |
|
Pemphigus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further stratification of the patient population by gender, age of disease onset, HLA-type, family history of autoimmune disease, history of anti-desmoglein (anti-Dsg) 3 or anti-Dsg1 antibody response, history of lesion morphology, and disease duration did not uncover significant associations between the PTPN22 1858T allele and PV subgroups.
|
21585555 |
2011 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against Dsg 3 and/or Dsg 1 could be detected in 71 (100%) of 71 PV sera and against Dsg 1 in 48 (96%) of 50 PF sera.
|
20163452 |
2010 |
|
Pemphigus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease caused by IgG autoantibodies that target Dsg1 and Dsg3 in pemphigus foliaceus and pemphigus vulgaris respectively.
|
20178466 |
2009 |