|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
|
31178865 |
2019 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
|
31781120 |
2019 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies.
|
29723379 |
2018 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
|
29740444 |
2018 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus and bullous pemphigoid (BP) are identified by autoantibodies (abs) against desmoglein 1, 3 (DSG1/3) and BP180/BP230, respectively.
|
28261028 |
2017 |
|
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients.
|
20163452 |
2010 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether individuals without pemphigus have B cell tolerance to Dsg1, we cloned mAbs from two patients with thrombotic thrombocytopenic purpura and a healthy person.
|
19843946 |
2009 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, immunofluorescence staining of A431DE cells (E-cadherin positive, Dsg1 negative) with pemphigus sera showed negative results.
|
18219275 |
2008 |
|
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of pemphigus-autoantigen desmoglein 1 in human thymus.
|
18331528 |
2008 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.
|
17640963 |
2007 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Ex vivo analysis of desmoglein 1-responsive T-helper (Th) 1 and Th2 cells in patients with pemphigus foliaceus and healthy individuals.
|
16026580 |
2005 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.
|
15841178 |
2005 |
|
Pemphigus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus.
|
14646976 |
2003 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus.
|
12058255 |
2002 |
|
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the reactivity of the sera from various types of pemphigus with recombinant proteins of extracellular and intracellular domains of human Dsg1 and Dsg3 by immunoblot analysis.
|
11154866 |
2001 |
|
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether pemphigus sera recognize non-denatured Dsg1 domains, constructs were expressed in cultured cells and tested for reactivity with pemphigus sera using live-cell immunofluorescence.
|
7543545 |
1995 |