|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus vulgaris (PV) is a rare autoimmune intraepithelial blistering skin disease characterized by the presence of circulating autoantibodies against desmoglein 3 (DSG3) and desmoglein 1 (DSG1), resulting in loss of the normal epithelial cell-to-cell adhesion, through a process called acantholysis.
|
28064226 |
2017 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3.
|
28661086 |
2017 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus vulgaris (PV) is a rare blistering skin disorder characterized by the disadhesion of keratinocytes due to autoantibody attack against epidermal targets including desmoglein (Dsg) 3, Dsg 1 and possibly other adhesion and non-adhesion molecules.
|
26911801 |
2016 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The desmosomal cadherin desmoglein-1 (DSG1) is an essential intercellular adhesion molecule that is altered in various human cutaneous disorders; however, its regulation and function in allergic disease remains unexplored.
|
24220297 |
2014 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion.
|
22996451 |
2012 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
This Commentary describes breakthroughs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated blistering skin diseases.
|
21056996 |
2010 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus.
|
17397555 |
2007 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Endemic pemphigus foliaceus (EPF) is a blistering skin disease characterized by autoantibodies against the desmosomal protein desmoglein 1.
|
12618858 |
2003 |
|
Dermatologic disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The mutation identified in this study is a novel mutation in the DSG1 gene and extends the body of evidence implicating the desmoglein gene family in the pathogenesis of human skin disorders.
|
12930313 |
2003 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Targetting of desmoglein 1 in inherited and acquired skin diseases.
|
12823304 |
2003 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus foliaceus is an autoimmune blistering skin disease characterized by intraepidermal blisters and circulating autoantibodies directed against desmoglein 1, a 160 kDa transmembrane desmosomal molecule expressed in keratinocytes.
|
12190860 |
2002 |
|
Dermatologic disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently we have identified a mutation in the DSG1 gene coding for desmoglein 1 as the cause of the autosomal dominant skin disease striate palmoplantar keratoderma (SPPK) in which affected individuals have marked hyperkeratotic bands on the palms and soles.
|
11313759 |
2001 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1, respectively.
|
9257868 |
1997 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Pemphigus foliaceus (PF) is a dermatosis characterized by subcorneal vesicles and pathogenic IgG autoantibodies against desmoglein 1.
|
9325073 |
1997 |