|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with mild-to-moderate essential hypertension in the HOMED-BP trial were randomly allocated to first-line treatment with a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB).
|
24192120 |
2013 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
The autoantibodies against angiotensin AT1 receptors (AT1-AAs) in patients with essential hypertension exhibited an agonistic action like angiotensin II and maintained high blood pressure (BP).
|
24131669 |
2014 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The relationship between angiotensinogen gene polymorphisms and essential hypertension in a Northern Han Chinese population.
|
23716723 |
2014 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
|
22974788 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
High risk for essential hypertension in males conferred by g.15241A>G polymorphism in intron 3 of AGT gene.
|
22799745 |
2013 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current meta-analysis suggested that AGT A-6G gene polymorphism might not be related to the increased risk of essential hypertension in the entire Chinese population.
|
22710764 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT.
|
22570327 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Functional polymorphisms that predispose to increased basal GRK4 activity both decrease dopamine receptor activity and increase angiotensin II type 1 (AT1) receptor activity and are associated with essential hypertension in a number of different human cohorts.
|
22407378 |
2012 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the positive association between angiotensinogen gene polymorphisms and haplotypes with essential hypertension is not simply explained by an increase in plasma angiotensinogen concentration.
|
22371359 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that three polymorphisms (A-6G, A-20C and G-217A) in the AGT gene are associated with essential hypertension in the Chinese population.
|
22156763 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to assess the association of the variants of AGT gene and the extent of risk involved in developing EH.
|
22148914 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Individuals carrying the mutated TT of AGT, DD of ACE and CC of AT1R genotypes had an 1.67 (P = 0.032), 3.09 (P < 0.001) and 3.45 (P < 0.001)-fold increased risk of HTA.
|
21779803 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between the M268T polymorphism in the angiotensinogen gene and essential hypertension in a South Indian population.
|
21312059 |
2011 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
Angiotensin II type 1 genotyping and relative telomere length were investigated by PCR in 40 patients of essential hypertension and 15 healthy controls.
|
21234654 |
2011 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the study is to explore the association of a new genetic marker of renin gene, and AGT gene M235T, A-6G, and A-20C polymorphisms and their haplotypes with EH in the Mongolian population.
|
20662730 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis with the aim of assessing the association of the angiotensin II type 1 (AT(1)) receptor gene A1166C polymorphism with essential hypertension in Chinese case-control studies.
|
20223791 |
2010 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
The angiotensinogen gene has been linked with human essential hypertension in whites but the relationship in Asian populations has been less consistent.
|
20216084 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population.
|
20087216 |
2010 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
Current pharmacological therapy of essential hypertension focuses on the regulation of vascular resistance by inhibition of hormones such as catecholamines and angiotensin II, blocking them from receptor activation.
|
20060896 |
2010 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
SNPs and AGT haplotypes were tested for association with plasma AGT, renal plasma flow (RPF), and essential hypertension.
|
19770777 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Human angiotensinogen (AGT) gene promoter polymorphisms (G-217A; A-20C; G-6A) influence AGT transcription in vitro and have been implicated in the genetics of essential hypertension.
|
19536167 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A case-control study of 538 individuals investigated whether the angiotensinogen gene (AGT) might be implicated in the pathogenesis of essential hypertension in the Hani and Yi populations of China.
|
19365726 |
2009 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, A6G polymorphism of the AGT gene could be a potential genetic marker for increased susceptibility to essential hypertension with or without T2DMin Malaysian subjects.
|
19243623 |
2009 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that AGT A-6G, T174 M and ACE-I/D were significantly associated with EH (AGT A-6G: AG+GG vs AA; OR=1.36; 95% CI=1.04-1.77.
|
18830250 |
2009 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin system gene polymorphisms are associated with essential hypertension; angiotensinogen gene variants are considered potential genetic risk factors.
|
18475146 |
2008 |