Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population. 26588355 2016
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The ACE, AGT, and eNOS genes were correlated with the development of renal function failure in IgAN, whereas the ACE and eNOS genes were associated with the degree of proteinuria and the development of renal function failure in MN. 24157068 2014
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Impact of polymorphisms of the genes encoding angiotensin II-forming enzymes on the progression of IgA nephropathy. 21150220 2012
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone. 21974877 2012
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-344T, and the angiotensin II type 1 receptor (AT1R) gene, A1166C, have been shown to be associated with IgA nephropathy (IgAN) and its progression. 21163122 2011
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Our results suggest that the AGT M235T polymorphism is associated with the progression of IgAN in Korean male patients. 19729965 2010
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Crosstalk between peroxisome proliferator-activated receptor-gamma and angiotensin II in renal tubular epithelial cells in IgA nephropathy. 19443277 2009
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 AlteredExpression disease LHGDN activated glomerular AGT expression is likely involved in elevated local ang II production and, thereby, may contribute to increased TGF-beta production and development of glomerular injury in IgA nephropathy 18421480 2008
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. 18421480 2008
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 AlteredExpression disease BEFREE Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1. 15458433 2005
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Among the ACE, AGT and ATR gene polymorphisms, only the DD genotype may predispose the individual to IgAN in the Chinese population. 15504143 2005
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The current approach to suppress the effects of angiotensin II, by angiotensin-converting enzyme inhibitors, angiotensin II receptor type 1 blockers, or both, as a cornerstone of the therapy of IgA nephropathy has been strengthened by recent studies. 15202611 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The effects of pIgA1 on the RAS were further examined in HMC incubated with IgA isolated from 30 patients with IgAN, 30 healthy subjects, and disease control subjects with other diseases. pIgA1 induction of angiotensin II or TGF-beta synthesis in HMC was significantly greater with preparations from patients with IgAN, compared with healthy or disease control subjects. 14638911 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Angiotensinogen gene variation and renoprotective efficacy of renin-angiotensin system blockade in IgA nephropathy. 12911556 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE A-20C angiotensinogen gene polymorphism and proteinuria in childhood IgA nephropathy. 14648325 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease LHGDN The AC/CC genotype of this polymorphism may be associated with an increased severity of proteinuria, suggesting that this polymorphism may play a significant role in the progression of IgA nephropathy in Japanese children. 14648325 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease LHGDN M235T and A (-20) C genotype of angiotensinogen can influence therapeutic efficacy of renin-angiotensin system blockade on renal survival in IgA nephropathy. 12911556 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Among the ACE, AGT and ATR gene polymorphisms, only the DD genotype may predispose the individual to IgAN in our Chinese population. 15153745 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Our results suggest that angiotensinogen-M235T polymorphism is an important marker of progression in IgA nephropathy in Caucasian patients, especially when analyzed in combination with ACE-I/D polymorphism. 15031629 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy. 12164881 2003
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Thus, the TT genotype of the AGT gene and the ID/DD genotype of the ACE gene are associated with increased severity of proteinuria, suggesting that AGT and ACE gene polymorphisms may play a significant role in the progression of IgA nephropathy in Japanese children. 11354780 2001
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Deletion/insertion polymorphism (D/I) of the angiotensin I converting enzyme gene, M235T polymorphism (T/M) of the angiotensinogen gene and A1166C polymorphism (C/A) of the angiotensin II type 1 receptor gene were determined in 274 Caucasian men with biopsy-proven IgAN (n = 86, 112, and 76 in stages 1, 2, and 3, respectively). 11053482 2000
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease CTD_human Our results suggest that polymorphisms at the AGT and ACE gene loci are important markers for predicting progression to chronic renal failure in Caucasian patients with IgA nephropathy. 9259580 1997
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Our results suggest that polymorphisms at the AGT and ACE gene loci are important markers for predicting progression to chronic renal failure in Caucasian patients with IgA nephropathy. 9259580 1997
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease CTD_human We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy. 9259580 1997