DUSP3, dual specificity phosphatase 3, 1845

N. diseases: 29; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1318973
Disease: Staphylococcus aureus infection
Staphylococcus aureus infection
0.010 Biomarker disease BEFREE Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 24901344 2014
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 Biomarker disease BEFREE Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 24901344 2014
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 Biomarker disease BEFREE Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 24901344 2014
CUI: C0205748
Disease: Dysplastic Nevus
Dysplastic Nevus
0.010 Biomarker disease BEFREE DUSP3, which regulates cellular senescence, was identified as one of the disease discriminative genes between DNs and common melanocytic nevi by three independent statistical approaches and its altered expression was confirmed by immunohistochemistry. 27377700 2016
CUI: C0027962
Disease: Melanocytic nevus
Melanocytic nevus
0.010 Biomarker disease BEFREE DUSP3, which regulates cellular senescence, was identified as one of the disease discriminative genes between DNs and common melanocytic nevi by three independent statistical approaches and its altered expression was confirmed by immunohistochemistry. 27377700 2016
CUI: C3665593
Disease: Melanocytic nevus of skin
Melanocytic nevus of skin
0.010 Biomarker disease BEFREE DUSP3, which regulates cellular senescence, was identified as one of the disease discriminative genes between DNs and common melanocytic nevi by three independent statistical approaches and its altered expression was confirmed by immunohistochemistry. 27377700 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.010 GeneticVariation group BEFREE Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. 29020102 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE DUSP3-/- bone marrow transfer to lethally irradiated DUSP3+/+ mice was sufficient to transfer the phenotype to DUSP3+/+ mice, indicating that hematopoietic cells compartment was involved in the increased tumour cell dissemination to lung tissues. 29020102 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE DUSP3 expression and activities are suggestive of a tumor suppressor or tumor-promoting enzyme in different types of human cancers. 30069819 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker phenotype BEFREE Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination. 29020102 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE Expression of VHR also suppressed tumor formation in a mouse xenograft model. 21262974 2011
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.310 AlteredExpression disease BEFREE Furthermore, VHR expression was significantly lower in NSCLC tissues in comparison to that in normal lung tissues. 21262974 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.020 Biomarker group LHGDN High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. 18311544 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications. 24886454 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE It has been suggested that vaccinia H1-related phosphatase can act as a tumor suppressor or tumor-promoting phosphatase in different cancers. 30208163 2018
CUI: C0019270
Disease: Hernia
Hernia
0.020 Biomarker phenotype BEFREE Mesh choice in VHR is important and was associated with hernia recurrence and wound complications in this population. 30080725 2020
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.010 Biomarker disease BEFREE Of these, three datasets (N=1023) were used to discover a set of three genes (GBP5, DUSP3, and KLF2) that are highly diagnostic for active tuberculosis. 26907218 2016
CUI: C0151332
Disease: Active tuberculosis
Active tuberculosis
0.010 Biomarker disease BEFREE Of these, three datasets (N=1023) were used to discover a set of three genes (GBP5, DUSP3, and KLF2) that are highly diagnostic for active tuberculosis. 26907218 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 Biomarker group BEFREE On the other hand, DUSP3 is implicated in human cancer. 24886454 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE On the other hand, DUSP3 is implicated in human cancer. 24886454 2014
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.010 Biomarker phenotype BEFREE Our results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner. 28848068 2017
CUI: C0243038
Disease: Carcinoma, Lewis Lung
Carcinoma, Lewis Lung
0.020 Biomarker disease BEFREE Our study demonstrates that DUSP3 phosphatase plays a key role in metastatic growth through a mechanism involving the recruitment of macrophages towards LLC-bearing lungs. 29020102 2017
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.310 Biomarker disease CTD_human Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). 15496427 2004
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 Biomarker disease BEFREE Taken together, these results suggest that PGG could be a potential therapeutic candidate for the treatment of cervical cancer through VHR inhibition. 31797547 2020
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker disease BEFREE Taken together, these results suggest that PGG could be a potential therapeutic candidate for the treatment of cervical cancer through VHR inhibition. 31797547 2020