|
Non-Small Cell Lung Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, VHR expression was significantly lower in NSCLC tissues in comparison to that in normal lung tissues.
|
21262974 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
|
15496427 |
2004 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
DUSP3 expression and activities are suggestive of a tumor suppressor or tumor-promoting enzyme in different types of human cancers.
|
30069819 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
It has been suggested that vaccinia H1-related phosphatase can act as a tumor suppressor or tumor-promoting phosphatase in different cancers.
|
30208163 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
DUSP3-/- bone marrow transfer to lethally irradiated DUSP3+/+ mice was sufficient to transfer the phenotype to DUSP3+/+ mice, indicating that hematopoietic cells compartment was involved in the increased tumour cell dissemination to lung tissues.
|
29020102 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications.
|
24886454 |
2014 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Expression of VHR also suppressed tumor formation in a mouse xenograft model.
|
21262974 |
2011 |
|
Hernia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Mesh choice in VHR is important and was associated with hernia recurrence and wound complications in this population.
|
30080725 |
2020 |
|
Hernia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
While efforts have been made by hernia surgeons to identify and address risk factors for postoperative wound events following VHR, the definition of these events lacks standardization.
|
29429064 |
2018 |
|
Carcinoma, Lewis Lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that DUSP3 phosphatase plays a key role in metastatic growth through a mechanism involving the recruitment of macrophages towards LLC-bearing lungs.
|
29020102 |
2017 |
|
Carcinoma, Lewis Lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
We finish the chapter by validating our results in DUSP3-knockout mice using in vivo angiogenesis assays such as Matrigel plug and Lewis lung carcinoma cell subcutaneous xenograft model followed by anti-CD31 immunofluorescence and ex vivo aortic ring assay.
|
27514814 |
2016 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
On the other hand, DUSP3 is implicated in human cancer.
|
24886454 |
2014 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
On the other hand, DUSP3 is implicated in human cancer.
|
24886454 |
2014 |
|
Prostatic Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.
|
19010898 |
2008 |
|
Prostatic Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.
|
18311544 |
2008 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The PPP2R1B tumor suppressor gene, encoding the beta isoform of the A subunit of serine/threonine-specific protein phosphatase 2A (PP2A-Abeta), located at 11q22-23, is inactivated in patients with cancer.
|
14767517 |
2004 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The PPP2R1B tumor suppressor gene, encoding the beta isoform of the A subunit of serine/threonine-specific protein phosphatase 2A (PP2A-Abeta), located at 11q22-23, is inactivated in patients with cancer.
|
14767517 |
2004 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that PGG could be a potential therapeutic candidate for the treatment of cervical cancer through VHR inhibition.
|
31797547 |
2020 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that PGG could be a potential therapeutic candidate for the treatment of cervical cancer through VHR inhibition.
|
31797547 |
2020 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that PGG could be a potential therapeutic candidate for the treatment of cervical cancer through VHR inhibition.
|
31797547 |
2020 |
|
Ventral Hernia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, the purpose of our study was to detail the variability of wound event definitions in recent ventral hernia literature and to propose standardized definitions for postoperative wound events following VHR.
|
29429064 |
2018 |
|
Lung Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.
|
29020102 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination.
|
29020102 |
2017 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a Lewis Lung carcinoma (LLC) experimental metastasis model, we observed that DUSP3-/- mice developed larger lung metastases than littermate controls.
|
29020102 |
2017 |
|
Endotoxemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner.
|
28848068 |
2017 |