Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
<b>Conclusion:</b> Overexpression of β-arrestin1 in the RVLM reduces BP and sympathetic outflow in hypertension, which may be associated with NFκB-mediated AT1R downregulation.
|
29643817 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
|
27298316 |
2016 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension is also associated with B cell activation and production of autoantibodies (anti-Hsp70, anti-Hsp65, anti-Hsp60, anti-AT1R, anti-α1AR, and anti-β1AR).
|
31321561 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
AT1R gene contributed to T2DM complicated by hypertension, but is only associated with cases of elevated systolic blood pressure.
|
12390711 |
2002 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated.
|
15863668 |
2005 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
AGTR1 polymorphism has been reported to associate with hypertension, myocardial infarction (MI), and metabolic traits.
|
17211857 |
2007 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R blockade could be beneficial in the treatment of HIVAN by ameliorating podocyte injury by avoiding the vicious cycle of nephron reduction and glomerular hypertension.
|
17229913 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome.
|
19023273 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome.
|
19023273 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
AT1R blockade and the deletion of the Agtr1a gene normalize the hypertension in hGRK4γ(142V) mice.
|
26667412 |
2016 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48-1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension.
|
28927645 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II receptor type 1 (AT1) antagonists are the most recent drug class against hypertension.
|
28957753 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.
|
29061726 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II receptor type 1 (AT1) antagonists are the most recent drug class against hypertension.
|
29156380 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension.
|
30311805 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension.
|
30380548 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
AGTR1 A1166C polymorphism predicted 9.8-year incident NAFLD (odds ratio: 1.67, 95% CI: 1.26-2.21) and hypertension (odds ratio: 1.49, 95% CI: 1.12-2.63) and 9-year increase in cardiovascular disease risk and endothelial dysfunction markers.
|
30920415 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have been reported in patients with disorders associated with hypertension.
|
31476909 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension.
|
9544872 |
1998 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A1166C polymorphism of angiotensin II type 1 receptor, blood pressure and arterial stiffness in hypertension.
|
15480098 |
2004 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure.
|
25031294 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A silent polymorphism (+1166 A/C single-nucleotide polymorphism) localized in the 3'-UTR (untranslated region) of the human angiotensin II type-1 receptor (AT1R) has been associated with hypertension and cardiovascular complications.
|
20966899 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
A transversion of adenine to cytosine at nucleotide position 1166 in the gene coding for the angiotensin-II type 1 receptor has been associated with hypertension in the non-diabetic population.
|
8671962 |
1996 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations.
|
12358135 |
2002 |