Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.
|
29701105 |
2018 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF.
|
26345849 |
2015 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results were independent of the etiology of the heart failure and suggest that increased levels of atrial AT1R mRNA may occur in response to elevated atrial pressures in heart failure.
|
9281460 |
1997 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 134 patients with HF and reduced systolic function for the AT1R A1166C genotype using polymerase chain reaction and restriction fragment length polymorphism.
|
18612202 |
2009 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Intracellular Ang-II and nuclear AT1R protein levels were significantly increased in a heart failure model in which atrial fibrosis underlies atrial fibrillation.
|
28381466 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
An upregulation in angiotensin II type 1 receptor expression was detected in medullary nuclei in WT CHF mice, which was significantly attenuated in SA mice with CHF.
|
22025374 |
2011 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R.
|
30050591 |
2018 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of this proof-of concept study provide the first evidence that the AGTR1 A1166C polymorphism could influence the response to candesartan in patients with heart failure who are receiving ACE inhibitors.
|
18594050 |
2008 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure.
|
31447777 |
2019 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial dysfunction was present in CHF group and the presence of ecNOS a allele and AT1R C allele further impaired EDD.
|
24992619 |
2014 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Blockade of angiotensin II type 1 receptor (AT1) signaling attenuates heart failure following myocardial infarction (MI), perhaps through reduction of fibrosis in the noninfarcted myocardium.
|
17208988 |
2007 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model.
|
27321284 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In human ventricles (n=13), message levels of atrial natriuretic peptide and AT(1) receptor were inversely correlated, which suggests a decrease in AT(1) receptor expression with progressive heart failure.
|
10715259 |
2000 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the pharmacology of a new class of compounds which display both AT1-receptor blocking properties combined with inhibition of neprilysin, the vasopeptidase enzyme degradating natriuretic peptide (ARNi), will be reviewed, alongside with their impact in the pathophysiology of chronic HF.
|
27075034 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings indicate that females are more susceptible to the adverse effects of AT1R stimulation than males favouring the development of HF and increased mortality.
|
29343862 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We compared the effects of sudden stretch to SFR as well as to twitch and Ca2+ transient characteristics in rat myocardium with monocrotaline-induced heart failure with those in normal rat myocardium without and with inhibition of angiotensin II type-1 (AT1) receptors.
|
29593122 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency.
|
18214293 |
2007 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It may underlie the decrease in AT1 protein expression in human heart failure.
|
9302352 |
1997 |
Congestive heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression.
|
21963897 |
2011 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
|
18586661 |
2008 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the AT1R-1166CC genotype is associated with increased ICD therapies in patients with chronic HF, and the level of circulating miR-155 may be a potential marker for arrhythmic risk.
|
22939041 |
2012 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, sensitization of the heart failure-promoting AT1 receptor by the RKIP-GRK2 interaction contributes to heart failure whereas dominant-negative GRK2-K220R is cardioprotective.
|
30687708 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sacubitril/valsartan (LCZ-696) is a combined neprilysin inhibitor and angiotensin AT1 receptor blocker approved in recent years for the treatment of chronic heart failure with reduced ejection fraction.
|
29286056 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mas and AT1 receptor protein expressions, Ang-(1-7) and Ang II levels in CHF increased.
|
28848201 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PVN expression of AT1R, HoxD10, and miR-7b was increased, whereas GABBR1 was lower in CHF.
|
26699387 |
2016 |