|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the heart failure treated with intracerebroventricular (ICV) infusion of angiotensin II type 1 receptor blocker (ARB), sympathetic activation and brain oxidative stress were significantly lower, and baroreflex sensitivity and volume tolerance were significantly higher than in heart failure treated with vehicle.
|
29495326 |
2018 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001.
|
29982608 |
2019 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure.
|
10937949 |
1999 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we demonstrate that a polymorphism in the AT1R gene (A1166C), linked to increased receptor activity, is associated with elevated levels of oxidative stress markers in heart failure patients but not in healthy controls.
|
16651460 |
2006 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because the increase in AT(1)R expression and transcription factor activation can be blocked by the AT(1)R antagonist losartan, a positive feedback mechanism of AT(1)R expression in CHF is suggested.
|
19717736 |
2009 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters.
|
31629013 |
2019 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data suggest that the serum levels of ghrelin are significantly positively correlated with Ang II in CHF patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF.
|
24465706 |
2014 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle.
|
19300450 |
2009 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients.
|
15569271 |
2004 |