|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
The heterodimerization of AT1R-AdipoR1 probably contributes to the renal injury of DN, and provides an additional mechanistic insight into how telmisartan prevents the development and progression of DN.
|
30699330 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor blocker (valsartan), suppresses renal injury in a pre-clinical model of early DN more effectively than valsartan monotherapy.
|
30909895 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The intensity of the correlation between AGTR1 A1166C polymorphism and DN susceptibility was evaluated through calculating pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs).
|
30313019 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN.
|
26619914 |
2016 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
TT genotypes of ACACβ gene and CC genotype of AGTR1 gene confers the risk of DN and both genes had significant epistatic interaction in Asian Indian patients with T2DM.
|
23081748 |
2013 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that the AGTR1 A1166C polymorphism may contribute to DN development, particularly in T2DM patients.
|
21607620 |
2012 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
As ANG II is an important modulator of hPTEC transcellular sodium reabsorption and function, glucose-mediated changes in hAT(1)R gene expression may participate in the pathogenesis of diabetic renal disease.
|
22647632 |
2012 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the AGTR1 gene may be associated with increased risk of diabetic nephropathy in men with type 1 diabetes.
|
21316998 |
2011 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our independent case-control study provides no evidence that common variants in ACE, ACE2 and AGTR1 play a major role in genetic susceptibility to diabetic nephropathy in a white population with Type1 diabetes.
|
20854388 |
2010 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the A allele, of the angiotensin II type 1 receptor (AGTR1) A1166C polymorphism, was associated with increased risk of overt DN (OR=3.04; 99% CI=1.02-9.06), independently of the other associated variables: age, duration of diabetes, ever smoking, HbA1c, and sex.
|
18413189 |
2009 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Homozygosity for the A allele, of the angiotensin II type 1 receptor (AGTR1) A1166C polymorphism, was associated with increased risk of overt DN (OR=3.04; 99% CI=1.02-9.06), independently of the other associated variables: age, duration of diabetes, ever smoking, HbA1c, and sex.
|
18413189 |
2009 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Angiotensin II type 1 receptor antagonists (AIIA) are beneficial for the prevention of atherosclerosis and diabetic nephropathy suggesting that angiotensin II (Ang II) promotes the development of these diseases.
|
17487826 |
2007 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of the renin-angiotensin system (RAS) in diabetic nephropathy, we examined the association between diabetic nephropathy in a large cohort of Japanese type 2 diabetic patients and polymorphisms within the genes that encode angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1).
|
17143591 |
2007 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Further, we discovered that the genes encoding the angiotensin-converting enzyme, angiotensinogen, and angiotensin II type I receptor have a significant combinational effect on conferring susceptibility to diabetic nephropathy.
|
17653210 |
2007 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Effect of genetic variation on therapy with angiotensin converting enzyme inhibitors or angiotensin receptor blockers in dialysis patients.
|
15946912 |
2005 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We examined eight polymorphic markers (D3S1512, D3S1550, D3S1557, D3S1744, D3S2326, D3S3599, D3S3694, and a (CA)(n) dinucleotide repeat polymorphism in the 3' flanking region of the AT1 gene) spanning about 6.2 megabases (Mb) in the region of maximal linkage with DN on chromosome 3q23-q24.
|
15364165 |
2004 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study compared the polymorphisms of angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene between type II diabetes with diabetic nephropathy (DN) in end-stage renal disease (ESRD) and those of the normal individuals in Taiwan.
|
12728975 |
2003 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the long-term effect of the angiotensin II subtype-1 (AT1) receptor antagonist losartan (100 mg o.d.) on kidney function in II and DD type 1 diabetic patients with diabetic nephropathy.
|
12716812 |
2003 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Previously, we reported evidence for linkage with diabetic nephropathy on chromosome 3q in a region encompassing the type 1 angiotensin II receptor (AGTR1) gene.
|
11863362 |
2002 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
RGD |
Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade.
|
12172324 |
2002 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that there is an association between the A1166-->C polymorphism of the angiotensin II type 1 receptor (AGT1R), glycemic control, and the risk of diabetic nephropathy in subjects with type 1 diabetes.
|
10969844 |
2000 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we investigated the interaction between long-term glycaemic control and three polymorphisms in the genes coding for AGTR1 (A1166-->C), angiotensin converting enzyme (ACE/ID) and angiotensinogen (M235T) on risk of developing diabetic nephropathy.
|
10907125 |
2000 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Risk of developing diabetic nephropathy is not associated with synergism between the angiotensin II (type 1) receptor C1166 allele and poor glycaemic control.
|
10328465 |
1999 |