|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of rs146292819 Polymorphism in ABCA1 Gene with the Risk of Coronary Artery Disease in Pakistani Population.
|
30945099 |
2019 |
|
Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for risk factors and clinical features, ABCA1 (p = 0.005) and SREBF2 (p = 0.010) gene expression were identified as independent predictors of CHD and severity.
|
30673762 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that three SNPs rs2230806, rs4149313, and rs9282541 in ABCA1 gene are significantly associated with susceptibility to CHD; further mechanism should be performed to be applied to drug research and development.
|
31006134 |
2019 |
|
Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the low-density lipoprotein receptor and ATP-binding cassette transporter A1 was markedly increased, indicating that the beneficial effect of statins in allergic asthma and coronary artery disease was mediated, at least in part, by decreasing cholesterol biosynthesis and foam cell formation.
|
31558320 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.
|
27560308 |
2016 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians.
|
26936456 |
2016 |
|
Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease.
|
26323267 |
2016 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.
|
26722555 |
2015 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the ABCA1-565C/T gene promoter polymorphism and coronary heart disease severity and cholesterol efflux in the Chinese Han population.
|
26090796 |
2015 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 R219K polymorphism is associated with CHD susceptibility, and individuals with ABCA1 have a significantly higher risk of cancer particularly in Asians.
|
25104170 |
2015 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis by ethnicity suggested that there were significant associations between the ABCA1 rs4149313 polymorphism and an increased risk of CHD in Asian populations, but not in Caucasian populations (all P > 0.05).
|
24942079 |
2014 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT.
|
21875686 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ATP-binding cassette transporter A1 R219K polymorphism and coronary artery disease in Chinese population: a meta-analysis of 5,388 participants.
|
23053993 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians.
|
21643759 |
2012 |
|
Coronary heart disease
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.
|
22419126 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that K allele of ABCA1 R219K polymorphism is a protective factor associated with decreased CHD susceptibility, but these associations vary in different ethnic populations.
|
21300560 |
2011 |
|
Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, of the 8 sex-biased genes at these loci, 4 have been directly linked to monogenic disorders of lipid metabolism and show an expression profile in females (elevated expression of ABCA1, APOA5 and LDLR; reduced expression of LIPC) that is consistent with the lower female risk of coronary artery disease.
|
21858147 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of the ATP-binding cassette transporter A1 R219K polymorphism with HDL-C level and coronary artery disease risk: a meta-analysis.
|
21310416 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present aim was to test if the ABCA1 C69T polymorphism influences CHD risk and response to statin treatment.
|
20595220 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of four polymorphisms in the ABCA1 gene (G1051A, G2706A, G2868A and -565C/T) with lipid profile and coronary artery disease.
|
21130966 |
2010 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The role of ATP-binding-cassette-transporter-A1 (ABCA1) gene polymorphism on coronary artery disease risk.
|
20303467 |
2010 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, common genetic variations of ABCA1 had a moderate influence on HDL-C levels and/or coronary heart disease in patients with T2D.These 2 effects were independent.
|
19059534 |
2009 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the R219K polymorphism of ABCA1 was associated with altered lipoprotein levels and the R219K variant significantly modulated the HDL-C response to pravastatin in Chinese patients with CHD.
|
19673941 |
2009 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, common genetic variations of ABCA1 had a moderate influence on HDL-C levels and/or coronary heart disease in patients with T2D.These 2 effects were independent.
|
19059534 |
2009 |