EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Disease: Bladder Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 Biomarker disease BEFREE A decrease in BC cell adhesion and tumor growth in vivo following PFN downregulation are observed, likely associated with the concomitant downregulation of Fibronectin receptor, Endothelin-1, and Actin polymerization. 27683119 2016
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 Biomarker disease BEFREE Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. 21183790 2011
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 AlteredExpression disease BEFREE Chromogranin A and endothelin-1 expression was evaluated by immunohistochemistry in prostate specimens of 114 men with prostate cancer who underwent radical retropubic prostatectomy and in 27 with bladder cancer who underwent radical cystectomy and served as controls. 20663522 2010
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 AlteredExpression disease BEFREE Proteins of the ET axis were frequently expressed in bladder cancer (ET-1 in 62% of tumours, ET(A)R in 93% of tumours, and ET(B)R in 84% of tumours). 18945538 2009
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 AlteredExpression disease LHGDN The role of the endothelin axis and microvessel density in bladder cancer - correlation with tumor angiogenesis and clinical prognosis. 17549358 2007
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.060 AlteredExpression disease LHGDN All cell lines expressed ET-1, and all but the RT-112 cell line produced ETAR, whereas no cell line expressed ET(B)R. The identification of the ET-axis at the mRNA and protein level in the majority of bladder tumor samples suggests a role in the carcinogenesis of bladder cancer. 15643502 2005