Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the relationships between ET1, cardiac morphology, and incident heart failure or cardiovascular death in participants with no evidence of clinical cardiovascular disease at the time ET1 was measured.
|
31515065 |
2020 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a vasoconstrictor associated with cardiovascular disease, whereas adrenomedullin (ADM) is a vasorelaxant with cardioprotective properties.
|
30987836 |
2019 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The angiotensin II AT<sub>1</sub> and the endothelin 1 ET<sub>A</sub> receptors play a crucial role in the pathogenesis of cardiovascular diseases like hypertension, heart failure, stroke, pulmonary hypertension, and cardiac hypertrophy.
|
30851407 |
2019 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endogenous ET-1 may be involved in progression of various cardiovascular diseases.
|
30352269 |
2019 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide considered to be causally implicated in hypertension and the development of cardiovascular disease.
|
31630572 |
2019 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress.
|
29738719 |
2018 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The present study evaluates the capacity of ET-1 to affect endothelin-1-associated hypertrophic activity and decreased expression of heme oxygenase-1 by H9c2 rat cardiomyoblasts in vitro, corresponding to in vivo processes underlying cardiovascular diseases (CVDs).
|
29354880 |
2018 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our findings demonstrate for the first time that PA increases ET-1 expression in endothelial cells through the induction of ER stress and the activation of PKC, providing novel mechanistic insights into the pathogenesis of obesity-associated hypertension and cardiovascular diseases.
|
29996135 |
2018 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
We tested the hypotheses that ET-1 reduces relaxing effects of NO and increases those of H<sub>2</sub> O<sub>2</sub> in resistance artery smooth muscle of patients with cardiovascular disease.
|
28686356 |
2018 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET1) synthesis is understood to promote cardiovascular diseases including acute cardiac transplant rejection; however, the contribution of ECM-derived chemokines (matrikines) to vascular inflammation remains poorly understood.
|
28790330 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Both endothelin-1 and oxidative stress have important roles in the development of cardiovascular diseases such as hypertension and atherosclerosis.
|
27682654 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) promotes renal damage during cardiovascular disease; yet, the molecular mechanisms involved remain unknown.
|
28230089 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
AAV delivery of ET1-shRNA is an effective therapeutic strategy for cold-related cardiovascular disease.
|
27736201 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1)-mediated vasoconstrictor tone is elevated in overweight and obese adults, contributing to vasomotor dysfunction and increased cardiovascular disease risk.
|
28635124 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In conclusion, with increased endothelin-1 levels after 3 years, the positive association between endothelin-1 and pulse pressure suggest subclinical haemodynamic changes with potential premature onset of cardiovascular disease in the black participants.
|
28726796 |
2017 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) plays an important role in the pathophysiology of diabetes-associated cardiovascular disorders.
|
27102411 |
2016 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor involved in many diseases, including certain cardiovascular disorders and cancer.
|
26607335 |
2016 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of endothelin-1 (ET-1), a potent vasoactive peptide, are implicated as a risk factor for cardiovascular diseases by exerting vasoconstriction.
|
26211713 |
2015 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) contributes to the pathogenesis of cardiovascular diseases with multiple properties such as vasoconstriction.
|
22396501 |
2012 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Since the JAK/STAT system is an important regulator of the response of endothelial cells to injury, the modulation of this system and the subsequent decrease in ET-1 level may represent a key pharmacological target in diabetes-associated cardiovascular disorders.
|
20217138 |
2010 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Traits of obstructive sleep apnea syndrome (OSAS) such as impaired ventilatory control, craniofacial abnormalities, and concomitant cardiovascular diseases are associated with modified endothelin-1 gene (EDN-1) or endothelin-receptor-subtype-a (EDNRA) gene.
|
20083432 |
2010 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production.
|
16332659 |
2005 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases.
|
15759050 |
2005 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
There is now also a wealth of evidence suggesting that endothelin-1 is a key mediator in a range of cardiovascular diseases associated with sustained vasoconstriction, such as chronic heart failure, and with vasospasm, such as subarachnoid haemorrhage.
|
9546947 |
1997 |