|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 traps as a potential therapeutic tool: from diabetes to beyond?
|
31394173 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P<sub>alb</sub> changes in models of diabetes and SCD.
|
31273050 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of the present study was to identify novel transcriptional mechanisms that influence ET-1 regulation in diabetes.
|
29947532 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling.
|
29870994 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously showed that endothelin-1 (ET-1) reduced diabetes-induced inflammation in hippocampal neurons, suggesting a neuroprotective effect.
|
29947543 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin system, including endothelin-1 (ET-1) and the receptors (ET(A) and ET(B)), is a likely candidate that may be involved in many aspects of the diabetes cerebrovascular disease.
|
29947530 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates important pathophysiological aspects of vascular response to insults.
|
27102411 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) plays a major role in regulating myocardial fibrosis in several pathological conditions, such as hypertension and diabetes.
|
25584774 |
2015 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate a novel glucose-induced mechanism of tissue damage, in which miR-1 regulates ET-1 expressions in diabetes.
|
24394957 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.
|
23077601 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that ERK5 signaling regulates glucose-induced ET-1 expression in diabetes.
|
20628425 |
2010 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since the JAK/STAT system is an important regulator of the response of endothelial cells to injury, the modulation of this system and the subsequent decrease in ET-1 level may represent a key pharmacological target in diabetes-associated cardiovascular disorders.
|
20217138 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate that in diabetes increased FN production and cardiomyocyte hypertrophy may be mediated through leptin with its interaction with ET-1.
|
19391127 |
2009 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, inhibition of this PKC isoform may prevent diabetes-related increase in ET-1.
|
18974277 |
2009 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A higher frequency of the Asn/Asn genotype of EDN1 was found in individuals with at least 10 years of diabetes and no retinopathy (controls) compared with DR patients with any duration of diabetes (DR: 2.3%; control: 11.0%; p=0.0002).
|
18806884 |
2008 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pathway by which the high-glucose environment of diabetes mediates increased levels of endothelins has not been completely elucidated but appears to involve endothelin-converting enzyme (ECE-1), which converts inactive big ET-1 to active ET-1 peptide.
|
15010576 |
2004 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Excessive stimulation of ET-1 production by, and activity in, MC is likely of pathogenic importance in glomerular damage in the setting of diabetes, hypertension, and glomerulonephritis.
|
12954590 |
2003 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Circulating and vascular endothelin-1 (ET-1) levels are elevated in diabetes, but the molecular components of the enzymatic activation of ET-1 in the vasculature remains unknown.
|
12477147 |
2002 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mean plasma ET-1 levels in diabetic patients with a family history of diabetes was found to be higher than patients with no family history of diabetes.
|
11358684 |
2001 |