EDN2, endothelin 2, 1907

N. diseases: 32; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003130
Disease: Anoxia
Anoxia 		0.010 AlteredExpression phenotype LHGDN Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. 12207323 2002
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE A role for endothelin-2 and its receptors in breast tumor cell invasion. 15059899 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 AlteredExpression group BEFREE In conclusion, the expression of human ET-2 in transgenic rats does not result in hypertension. 8587401 1995
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 AlteredExpression group BEFREE These data show that the elevation in endothelin-2 expression in this transgenic model does not induce hypertension but leads to changes at the end-organ level. 10494802 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 GeneticVariation group BEFREE The difference in genotype and allele frequencies between the extremes of blood pressure suggest that the ET2 locus influences the severity rather than the initial development of hypertension. 10489105 1999
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 Biomarker group LHGDN Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. 12516960 2002
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 Biomarker group BEFREE A role for endothelin-2 and its receptors in breast tumor cell invasion. 15059899 2004
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group BEFREE The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for AF in patients with HCM. 18037749 2007
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group LHGDN The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for AF in patients with HCM. 18037749 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE The clinical implication supports the view that EDN3, in contrast to EDN1 and EDN2, may act as natural tumour suppressor in the human mammary gland. 19527488 2009
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.010 Biomarker group BEFREE This Edn2-mediated retinopathy was reduced by all treatments. 29248456 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 Biomarker group BEFREE The assessment of mRNA gene expression and plasma concentration of ET-1, ET-2, ET-3 was conducted in the first, third and seventh day following the onset of stroke using qRT-PCR method and ELISA tests. 30047329 2018
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.010 GeneticVariation group BEFREE Some polymorphisms of the EDN1, EDN2 and EDNRA genes may influence susceptibility to vascular diseases. 16879056 2006