|
Hypotension
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
|
1309933 |
1992 |
|
Bradycardia
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
|
1309933 |
1992 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
RGD |
Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo.
|
10573185 |
1999 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
The influence of endothelin on vascular and myocardial reperfusion damage was studied with exogenous endothelin-2.
|
1479622 |
1992 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Hypertensive disease
|
0.030 |
AlteredExpression
|
group |
BEFREE |
These data show that the elevation in endothelin-2 expression in this transgenic model does not induce hypertension but leads to changes at the end-organ level.
|
10494802 |
1999 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The difference in genotype and allele frequencies between the extremes of blood pressure suggest that the ET2 locus influences the severity rather than the initial development of hypertension.
|
10489105 |
1999 |
|
Hypertensive disease
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In conclusion, the expression of human ET-2 in transgenic rats does not result in hypertension.
|
8587401 |
1995 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
A role for endothelin-2 and its receptors in breast tumor cell invasion.
|
15059899 |
2004 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells.
|
12516960 |
2002 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma.
|
31629215 |
2019 |
|
Eclampsia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of eNOS G894T and ET-2 A985G genes are correlated with the occurrence of eclampsia.
|
31486478 |
2019 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This Edn2-mediated retinopathy was reduced by all treatments.
|
29248456 |
2018 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
The assessment of mRNA gene expression and plasma concentration of ET-1, ET-2, ET-3 was conducted in the first, third and seventh day following the onset of stroke using qRT-PCR method and ELISA tests.
|
30047329 |
2018 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study aims to find out whether mRNA expressions and plasma concentrations of endothelin-1 (ET-l), endothelin-2 (ET-2) and endothelin-3 (ET-3) remain different in IS sufferers with low HcT and Hb levels in comparison with those whose HcT i Hb levels during a severe IS episode remain within the norm.
|
30047329 |
2018 |
|
Rett Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of exocytosis-related genes (Stx5a, Syt6), genes encoding secretory (Fgf2, Fgf4, Edn2) and synaptic proteins (Grin2b, Gabbr1), neurotrophin signaling-associated genes (Sos1, Shc1, Traf6, Psen2), and a gene for Rett syndrome (Mecp2) were significantly changed.
|
28041965 |
2017 |
|
Malignant tumor of colon
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Mechanistic studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines.
|
22865632 |
2013 |
|
Colon Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
|
22865632 |
2013 |
|
Photoreceptor degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.
|
23469133 |
2013 |
|
Polycystic Ovary Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In GLCs from women with PCOS, Endothelin-1 mRNA expression was elevated (2.2-fold) as compared with normally ovulating women, whereas endothelin-2 mRNA was reduced (1.8-fold).
|
22727793 |
2012 |
|
Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since endothelin 2 is potently vasoconstrictive and was produced by microglia/macrophages, our data provide what we believe to be a novel link between these cell types and vascular dysfunction in glaucoma.
|
21383504 |
2011 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The clinical implication supports the view that EDN3, in contrast to EDN1 and EDN2, may act as natural tumour suppressor in the human mammary gland.
|
19527488 |
2009 |