|
Movement Disorders
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Neoplasms
|
0.060 |
PosttranslationalModification
|
group |
BEFREE |
Lastly, silencing of Ephrin-B3 decreases tumor vascularization and growth in a xenograft mice model.
|
28423606 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We found that Ephrin B3 was concomitantly expressed with EphA2 and Ephrin A1 with higher Ephrin B3 levels found in non-squamous than in squamous tumors, whereas EphA2 was higher expressed in well-differentiated than in low-differentiated tumors.
|
27533087 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In human glioma specimens, ephrin-B3 expression and phosphorylation correlated with increasing tumor grade.
|
16951161 |
2006 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In this study, we showed that EFNB2 and TrkA expressions were associated with both tumor stage and age, whereas EPHB6 and EFNB3 expressions were solely associated with tumor stage, suggesting that these genes were expressed in distinct subsets of NB.
|
10984508 |
2000 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Higher levels of EPHB6, EFNB2, and EFNB3 expression were found in low-stage tumors (stage 1, 2, and 4S) than in advanced-stage tumors (stage 3 and 4; P = 0.0013, P = 0.0048, and P = 0.027, respectively).
|
10389937 |
1999 |
|
Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Childhood Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, if any one of the four genes (EPHB6, EFNB2, EFNB3, or TrkA) was expressed at high levels in NB, the patient survival was excellent (>90%).
|
10984508 |
2000 |
|
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, if any one of the four genes (EPHB6, EFNB2, EFNB3, or TrkA) was expressed at high levels in NB, the patient survival was excellent (>90%).
|
10984508 |
2000 |
|
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, if any one of the four genes (EPHB6, EFNB2, EFNB3, or TrkA) was expressed at high levels in NB, the patient survival was excellent (>90%).
|
10984508 |
2000 |
|
Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data suggest that high-level expression of EPHB6, EFNB2, and EFNB3 is associated with favorable NB and that low-level expression of EPHB6, EFNB2, and EFNB3 correlates with aggressive MYCN-amplified NB.
|
10389937 |
1999 |
|
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data suggest that high-level expression of EPHB6, EFNB2, and EFNB3 is associated with favorable NB and that low-level expression of EPHB6, EFNB2, and EFNB3 correlates with aggressive MYCN-amplified NB.
|
10389937 |
1999 |
|
Childhood Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data suggest that high-level expression of EPHB6, EFNB2, and EFNB3 is associated with favorable NB and that low-level expression of EPHB6, EFNB2, and EFNB3 correlates with aggressive MYCN-amplified NB.
|
10389937 |
1999 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Considering the significant associations of EFNB3 SNPs with hypertension in hypogonadic males and supporting evidence from castrated EFNB3 KO mice, we conclude that loss-of-function variants of molecules in the EPHB6 signaling pathway in the presence of testosterone are protective against hypertension in humans.
|
30262919 |
2018 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate.
|
28423606 |
2017 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, our investigation has shown that EFNB3 is a hypertension risk gene in certain individuals.
|
28272517 |
2017 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate.
|
28423606 |
2017 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate.
|
28423606 |
2017 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate.
|
28423606 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of Ephrin B3 was furthermore analyzed in a cohort of NSCLC stage IA-IB cases (n=200) alongside EphA2 and Ephrin A1.
|
27533087 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Here we show for the first time that blocking expression of the Eph ligand Ephrin B3 inhibits NSCLC cell migration and invasion.
|
27533087 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identify and describe Ephrin B3 as a putative signaling molecule involved in the response of NSCLC cells to combined treatment with PKC 412 and ionizing radiation.
|
23303128 |
2013 |