EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Disease: Metastatic malignant neoplasm to brain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 Biomarker disease BEFREE Several targeted therapies-such as tyrosine kinase inhibitors targeting epidermal growth factor receptors and anaplastic lymphoma kinase-are active in NSCLC and have data to suggested possible effectiveness against brain metastases in these patients. 30176786 2019
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 Biomarker disease BEFREE Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status. 29552209 2018
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 GeneticVariation disease BEFREE We explored whether activating mutations of epidermal growth factor receptors (<i>EGFRs</i>) in exon 19 deletion or L858R predict BM in NSCLC. 28881820 2017
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 Biomarker disease BEFREE EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. 23794705 2013
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 Biomarker disease BEFREE EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer. 23249107 2012
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 AlteredExpression disease BEFREE Metastases showed significantly higher immunohistochemical expression of EGF (membrane: brain metastases 66.0 versus primary tumors 48.5; P = 0.027; nucleus: brain metastases 92.2 versus 67.4; P = 0.008), amphiregulin (nucleus: brain metastases 53.7 versus primary tumors 33.7; P = 0.019), phosphorylated EGFR (membrane: brain metastases 161.5 versus primary tumors 76.0; P < 0.0001; cytoplasm: brain metastases 101.5 versus primary tumors 55.9; P = 0.014), and phosphorylated Her3 (membrane: brain metastases 25.0 versus primary tumors 3.7; P = 0.001) than primary tumors did. 19622585 2009
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 AlteredExpression disease BEFREE Polysomy of chromosome 7 is associated with amplification and overexpression of the EGF-receptor gene in a human carcinoma cell line derived from a brain metastasis. 1701094 1990
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.080 Biomarker disease BEFREE Nineteen per cent (five out of 27) of the gliomas, 50% (three out of six) of the brain metastases and 0% (0 out of 11) meningiomas had an amplified EGF-receptor gene. 2908290 1988