|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We also detected a nominal association of 4 SNPs (rs6747506, rs6718289, rs2229294, and rs3813226) of the EGR4 gene that form strong linkage disequilibrium with schizophrenia in males.
|
22691714 |
2012 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
We also detected a nominal association of 4 SNPs (rs6747506, rs6718289, rs2229294, and rs3813226) of the EGR4 gene that form strong linkage disequilibrium with schizophrenia in males.
|
22691714 |
2012 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
EGR genes, including EGR2, EGR3, and EGR4, showed significant association with schizophrenia in Japanese schizophrenic pedigrees.
|
20687139 |
2010 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Four of these genes (PPP3CC, EGR2, EGR3, and EGR4) showed nominally significant association with schizophrenia.
|
17360599 |
2007 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Four of these genes (PPP3CC, EGR2, EGR3, and EGR4) showed nominally significant association with schizophrenia.
|
17360599 |
2007 |
|
Bipolar I disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
None of the SNPs tested in EGR1, EGR2, or EGR4 was associated with child BP-I.
|
22370066 |
2012 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Biomarker
|
disease |
RGD |
Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke.
|
22645329 |
2012 |
|
Male infertility
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
To date, this study is the first to screen the EGR4 gene in relation to male infertility.
|
28464846 |
2017 |
|
Cryptorchidism
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular biological observations favor LH deficiency, with EGR4 as a master regulatory gene in Leydig cell dysgenesis, as the reason for impaired mini-puberty, and recent evidence supports the idea that infertility in cryptorchidism is a consequence of alterations in the Piwi pathway.
|
26642196 |
2015 |
|
Cryptorchidism
|
0.020 |
Biomarker
|
disease |
BEFREE |
EGR4 is a master gene responsible for fertility in cryptorchidism.
|
19828938 |
2009 |
|
Male infertility
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These data raise the possibility that Egr4 may contribute to some forms of human idiopathic male infertility.
|
10529423 |
1999 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gain-of-function and loss-of-function assays demonstrated that both ZNF205-AS1 and EGR4 promoted NSCLC cell growth in vitro and NSCLC tumour growth in vivo.
|
30556283 |
2019 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Gain-of-function and loss-of-function assays demonstrated that both ZNF205-AS1 and EGR4 promoted NSCLC cell growth in vitro and NSCLC tumour growth in vivo.
|
30556283 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
EGR4 may play a role in the occurrence and development of BC.
|
31844579 |
2019 |
|
Ischemic stroke
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.
|
29580816 |
2018 |
|
Leydig cell agenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular biological observations favor LH deficiency, with EGR4 as a master regulatory gene in Leydig cell dysgenesis, as the reason for impaired mini-puberty, and recent evidence supports the idea that infertility in cryptorchidism is a consequence of alterations in the Piwi pathway.
|
26642196 |
2015 |
|
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that EGR4 likely regulates the bone metastasis and proliferation of SCLC cells via transcriptional regulation of several target genes, and may therefore be a promising target for the development of anticancer drugs for SCLC patients.
|
25411851 |
2014 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that EGR4 likely regulates the bone metastasis and proliferation of SCLC cells via transcriptional regulation of several target genes, and may therefore be a promising target for the development of anticancer drugs for SCLC patients.
|
25411851 |
2014 |
|
Pituitary Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, we found multiple differences in gene expression between the high and low infertility risk groups, confirming the importance of an intact hypothalamo-pituitary testicular axis and EGR4 in fertility development.
|
19828938 |
2009 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hereby, samples from precursor B-cell acute lymphoblastic leukemia (ALL) could be distinguished from cases of acute myeloid leukemia by virtue of N33, EGR4, CDC2, CCND2, or MOS hypermethylation in ALL.
|
15538567 |
2005 |
|
Oligospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice.
|
10529423 |
1999 |
|
Incomplete spermatogenic arrest
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice.
|
10529423 |
1999 |
|
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The nerve growth factor-induced clone C (NGFI-C) gene encodes a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in brain.
|
1584812 |
1992 |