METTL21C, methyltransferase like 21C, 196541

N. diseases: 5; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678909
Disease: Brain Waves
Brain Waves 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. 29947131 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.020 GeneticVariation disease BEFREE Our study, for the first time, demonstrates that the polymorphisms and haplotypes of METTL21C contribute to the peak BMD and TFM in Chinese males, which suggests that as a quantitative trait locus with potential pleiotropy it may have an influence on osteoporosis and obesity. 27628047 2017
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.020 Biomarker disease BEFREE METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway. 24677265 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation disease BEFREE Our study, for the first time, demonstrates that the polymorphisms and haplotypes of METTL21C contribute to the peak BMD and TFM in Chinese males, which suggests that as a quantitative trait locus with potential pleiotropy it may have an influence on osteoporosis and obesity. 27628047 2017
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.010 Biomarker disease BEFREE Relevant findings included: (1) hypomethylation caused by rare genetic variants (meSNVs) at six loci (ERMN, USP24, METTL21C, PDE10A, STX16 and DBT) significantly associated with ASD (q-value <0.05); and (2) clustered epimutations associated to transcriptional changes in single-ASD patients (n=4). 27404287 2016
CUI: C0872084
Disease: Sarcopenia
Sarcopenia 		0.010 Biomarker phenotype BEFREE METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway. 24677265 2014