ELANE, elastase, neutrophil expressed, 1991

N. diseases: 346; N. variants: 33
Disease: Bacterial Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.040 Biomarker group BEFREE We sought to investigate if NE could be used as a biomarker for bacterial infection in patients with COPD. 31362723 2019
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.040 AlteredExpression group BEFREE IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). 29884450 2018
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.040 Biomarker group BEFREE When challenged i.p., mice deficient in either MPO or NE were markedly more susceptible to bacterial infection and death. 15661916 2005
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.040 GeneticVariation group BEFREE This study underlines the importance of ELA2 molecular screening to identify patients who may be at particular risk of severe bacterial infections and/or acute myeloid leukemia/myelodysplasia. 14962902 2004