ELANE, elastase, neutrophil expressed, 1991

N. diseases: 346; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.050 AlteredExpression group BEFREE The neutrophil elastase and myeloperoxidase mRNA levels showed significant positive correlation with BMI, serum triglyceride, atherogenic index of plasma and 10-year risk of developing cardiovascular disease. 30056589 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.050 AlteredExpression group BEFREE In individuals without cardiovascular disease, MDA levels decreased in those involved in walking/square dancing or taiji/yoga, SOD activity increased in those performing walking/square dancing, and 4-HNE levels decreased in those involved in taiji/yoga. 30065938 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.050 Biomarker group BEFREE Linear and logistic regression analysis evidenced strong associations between the IMT or the Framingham CVD risk category and blood GSSG/GSH or serum HNE protein adducts in the S-O group. 29452783 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.050 Biomarker group BEFREE Consequently, inhibition of NE may represent a potential therapeutic approach to treating cardiovascular disease. 29437605 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.050 GeneticVariation group BEFREE Identification and functional characterization of variants in the neutrophil elastase (ELA2) gene in cardiovascular disease. 17622939 2007