ELANE, elastase, neutrophil expressed, 1991

N. diseases: 346; N. variants: 33
Disease: Inflammation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation 		0.040 AlteredExpression phenotype LHGDN The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation. 17397908 2007
CUI: C0021368
Disease: Inflammation
Inflammation 		0.040 AlteredExpression phenotype LHGDN Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. 15140022 2004
CUI: C0021368
Disease: Inflammation
Inflammation 		0.040 Biomarker phenotype LHGDN Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. 12114510 2002
CUI: C0021368
Disease: Inflammation
Inflammation 		0.040 Biomarker phenotype LHGDN Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. 12444202 2002