|
Hepatocellular Adenoma
|
0.500 |
Biomarker
|
disease |
RGD |
Distinctive immunohistochemical staining for alpha(2)M could be consistently demonstrated in GST-P-negative HAF, HCA, and HCC induced not only by peroxisome proliferators but also N-nitrosodiethylamine alone.
|
15509519 |
2004 |
|
Hepatocellular Adenoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Distinctive immunohistochemical staining for alpha(2)M could be consistently demonstrated in GST-P-negative HAF, HCA, and HCC induced not only by peroxisome proliferators but also N-nitrosodiethylamine alone.
|
15509519 |
2004 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the subunit and conformational structure of alpha(2)M in AD plasma samples, and its capacity to bind trypsin, transforming growth factor-beta1, and Abeta.
|
14678766 |
2003 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Substantial linkage disequilibrium was detected across the gene as a whole, and haplotype analysis also showed significant association between AD and groups of A2M polymorphisms.
|
12966032 |
2003 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggest that attenuation of IL-1beta-induced alpha(2)M synthesis/release by blocking NF-kappaB activation may potentially be 'protective' against the development of late-onset AD.
|
12399113 |
2002 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we conclude that in our samples, the A2M I/V genotype might be a susceptibility variant, even with minor effect, for both sporadic AD and PD.
|
12133586 |
2002 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, our studies do not support the A2M polymorphisms as a risk factor for Alzheimer disease.
|
12116268 |
2002 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy.
|
12221172 |
2002 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results from this study indicate that polymorphisms in LRP and A2M are not associated with increased risk for AD in Northern Ireland.
|
11496365 |
2001 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data suggests that the A2M D allele is a modest risk factor for late-onset sporadic AD in Koreans, and the AD risk conferred by the A2M D allele increases in APOE epsilon4 negative subjects.
|
11231028 |
2001 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.
|
11455130 |
2001 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics.
|
10688047 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the fact that the previously reported positive association between A2M deletion polymorphism and AD modifies the disease risk in the studied population.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:775-777, 2000.
|
11121179 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results failed to demonstrate an association between this polymorphism and Japanese sporadic AD, and the A2M I1000V mutation does not seem to be a risk factor per se for sporadic AD.
|
10936700 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the brain of Alzheimer's disease (AD) patients, alpha(2)M has been localized to diffuse amyloid plaques. alpha(2)M also binds soluble beta-amyloid, of which it mediates degradation.
|
10959035 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent reports have suggested that genetic polymorphisms in the alpha-2 macroglobulin (A2M) gene are associated with an increased risk for Alzheimer's disease.
|
11058789 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer's disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of alpha(2)-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and alpha(1)-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese.
|
11099722 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (apoE), the lipoprotein receptor related protein (LRP) and alpha-2 macroglobulin (alpha2M) have been proposed as a functional complex involved in amyloid clearance, a crucial event for Alzheimer's disease development.
|
10961667 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that the BBB removes Ass from the brain largely via age-dependent, LRP-1-mediated transport that is influenced by alpha(2)M and/or apoE, and may be impaired in AD.
|
11120756 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic association between alpha-2 macroglobulin and Japanese sporadic Alzheimer's disease.
|
10477120 |
1999 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference in the severity of CAA between individuals with the A2M deletion allele and those without in the AD, non-AD, or total cases.
|
10548657 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that there is no genetic association between A2M and AD in our case-control sample.
|
10462112 |
1999 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
|
10203250 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
|
9811940 |
1998 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
|
9697696 |
1998 |