GKN2, gastrokine 2, 200504

N. diseases: 19; N. variants: 0
Disease: Stomach Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 Biomarker disease BEFREE GKN2 also inhibited xenograft tumor growth and was an independent and significant prognostic factor for patients with gastric cancer treated with oxaliplatin. 31382983 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 Biomarker disease BEFREE Collectively, our data demonstrated that the interaction between GKN2 and TFF1 can have synergistic antiproliferative and pro-apoptotic effects on gastric cancer. 28150071 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 AlteredExpression disease BEFREE Our results suggested, for the first time, that the gradual change in GDDR expression might not only be directly related to H. pylori infection but also be an early molecular event in the development of gastric carcinoma. 26842925 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 AlteredExpression disease BEFREE In mouse models of GC, decreased GKN2 expression correlated with gastric pathology that paralleled human GC progression. 26974160 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 AlteredExpression disease BEFREE In this study, we investigated the expression and biological functions of GKN2 and its interaction with TFF2 in gastric cancer. 24408014 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 AlteredExpression disease BEFREE Expression of gastrokine‑2 protein was reduced or absent in gastric cancer tissues and gastric cancer cell lines. 25270871 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 Biomarker disease BEFREE In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner. 21870107 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.080 AlteredExpression disease BEFREE This indicates that TFF1 expression in the absence of TFIZ1 expression has potentially deleterious consequences in gastric cancer. 18722547 2009