|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.
|
23792811 |
2013 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.
|
23792811 |
2013 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of EN2 in urine was highly predictive of PC, with a sensitivity of 66% and a specificity of 88.2%, without requirement for DRE.
|
21364037 |
2011 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of EN2 in urine was highly predictive of PC, with a sensitivity of 66% and a specificity of 88.2%, without requirement for DRE.
|
21364037 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The urinary level of engrailed-2 (EN2) protein has been recently suggested as a promising PC biomarker, correlating with tumour volume and stage.
|
31692391 |
2020 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our findings indicate that EN2 secretion by tumors may be a means of preventing viral-mediated immune invasion of tissue immediately adjacent to the tumor.
|
30914795 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we analyzed 1) the expression/secretion profile of EN2 in five independent samples cohorts from PCa patients and controls (prostate tissues and/or urine) to determine its utility as a PCa biomarker; and 2) the functional role of EN2 in normal (RWPE1) and tumor (LNCaP/22Rv1/PC3) prostate cells to explore its potential value as therapeutic target.
|
31500112 |
2019 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
The methylation status of the EN2 gene was revealed to be associated with histological grade and tumor size in cc-RCC.
|
29151918 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
EN2 knockdown significantly promoted cell cycle arrest and apoptosis of BC cells with inhibition of proliferation and invasion in vitro as well as EN2 knockdown decreased the tumor growth of BC.
|
25812440 |
2015 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Furthermore, expression of EN2 protein was negatively correlated with increasing histological grade of CCRCC tumors (P = 0.003).
|
24532139 |
2014 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer.
|
21364037 |
2011 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our findings indicate that EN2 secretion by tumors may be a means of preventing viral-mediated immune invasion of tissue immediately adjacent to the tumor.
|
30914795 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of EN2 inhibited the proliferation of A549 cells <i>in vitro</i>, and suppressed their migration and invasion.
|
29963129 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, re-activation of the EN2 gene markedly inhibited the proliferative and invasive capacities of cc-RCC.
|
29151918 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, cell proliferation, apoptosis and invasion assays were conducted to analyze the inhibitory effects of EN2 re-expression in 786-O cells.
|
29151918 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.
|
26948025 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
EN2 knockdown significantly promoted cell cycle arrest and apoptosis of BC cells with inhibition of proliferation and invasion in vitro as well as EN2 knockdown decreased the tumor growth of BC.
|
25812440 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, expression of EN2 protein was negatively correlated with increasing histological grade of CCRCC tumors (P = 0.003).
|
24532139 |
2014 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To clarify the localization and expression of EN2 in renal cell carcinoma, anti-EN2 antibody (ab28731) and anti-EN2 antibody (MAB2600) were used for immunohistochemistry (IHC) respectively.
|
24786097 |
2014 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we investigate the role of miR‑212 on EN-2 expression and explored the mechanism of prostate cancer survival and metastasis.
|
28713997 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In pcDNA-EN-2 and miR-33a mimic co-transfected PC3 and DU145 cells, EN-2 overexpression reverses the anti-cell survival and metastasis actions of miR-33a overexpression.
|
27921232 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that the functional interaction of miR-33a and EN-2 is involved in tumorigenesis of prostate cancer.
|
27921232 |
2017 |
|
Pervasive Development Disorder
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Whole-exome sequencing identifies a novel heterozygous missense variant of the EN2 gene in two unrelated patients with autism spectrum disorder.
|
27755371 |
2016 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.
|
26948025 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In vitro invasion and migration assays and in vivo experiments were carried out to examine the functions of EN2 in BC invasion and metastasis.
|
25812440 |
2015 |