EN2, engrailed homeobox 2, 2020

N. diseases: 41; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 AlteredExpression phenotype BEFREE The exact role of EN2 expression in renal carcinoma carcinogenesis requires further investigation. 24532139 2014
CUI: C0524528
Disease: Pervasive Development Disorder
Pervasive Development Disorder 		0.030 GeneticVariation group BEFREE Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. 16252243 2005
CUI: C0524528
Disease: Pervasive Development Disorder
Pervasive Development Disorder 		0.030 AlteredExpression group BEFREE Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. 15024396 2004
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 Biomarker disease BEFREE Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. 29894832 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 Biomarker disease BEFREE It is hoped that further work will validate its use as a biomarker, and provide insight into the role of EN2 in the development, progression and spread of ovarian cancer. 30285763 2018
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 Biomarker disease BEFREE Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. 29894832 2018
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 Biomarker disease BEFREE It is hoped that further work will validate its use as a biomarker, and provide insight into the role of EN2 in the development, progression and spread of ovarian cancer. 30285763 2018
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.020 Biomarker disease BEFREE We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. 30285763 2018
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.020 Biomarker disease BEFREE Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. 29894832 2018
CUI: C0023015
Disease: Language Disorders
Language Disorders 		0.020 Biomarker group BEFREE Additionally, two other genes on 7q31-36, FOXP2 and the EN2 genes are also found to play a role in language impairment. 22522212 2012
CUI: C0023015
Disease: Language Disorders
Language Disorders 		0.020 GeneticVariation group BEFREE Studies investigating association between markers at EN2 (chr7q36), a location associated with language disorders, and autism reveal mixed findings. 17948868 2008
CUI: C1519176
Disease: Salivary Gland Pleomorphic Adenoma
Salivary Gland Pleomorphic Adenoma 		0.010 Biomarker disease BEFREE There was no significant correlation between urinary EN2 and serum PSA, tumour staging and grading. 31692391 2020
CUI: C0154823
Disease: Retinal defect
Retinal defect 		0.010 GeneticVariation phenotype BEFREE Retinal defects in mice lacking the autism-associated gene Engrailed-2. 30980901 2019
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 AlteredExpression group BEFREE Adenocarcinoma human alveolar basal epithelial A549 cells were transfected with negative control plasmids or those containing EN2, enabling its overexpression. 29963129 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 AlteredExpression disease BEFREE The present study demonstrated that expression of EN2 in NSCLC tissues was downregulated and negatively associated with the degree of disease differentiation, lymphatic metastasis and clinical staging. 29963129 2018
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis 		0.010 AlteredExpression disease BEFREE The present study demonstrated that expression of EN2 in NSCLC tissues was downregulated and negatively associated with the degree of disease differentiation, lymphatic metastasis and clinical staging. 29963129 2018
CUI: C0150080
Disease: Social Communication Disorder
Social Communication Disorder 		0.010 Biomarker disease BEFREE Engrailed-2 (En2) is a transcription factor critical for neural development, and mice lacking En2 (En2<sup>-/-</sup>) display signs of impaired social interaction, cognitive processes (e.g., learning and memory, conditioned fear), and neurodevelopmental alterations. 29953887 2018
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.010 Biomarker disease BEFREE We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. 30285763 2018
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.010 Biomarker group BEFREE Recently, HCMV infection and engrailed-2 have been reported to be related to the autism spectrum disorder (ASD). 28343438 2017
CUI: C0017638
Disease: Glioma
Glioma 		0.010 AlteredExpression disease BEFREE We further found that the miR-27b transfected glioma U251 cells exhibited longer cell bodies with more synapses and multiple-angle shapes; moreover, Western blot detection revealed that the EN2 protein levels in these cells were significantly low. 28343438 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 PosttranslationalModification phenotype BEFREE Engrailed-2 promoter hyper-methylation is associated with its downregulation in clear cell renal cell carcinoma. 29151918 2017
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.010 Biomarker disease BEFREE EN2 knockdown significantly promoted cell cycle arrest and apoptosis of BC cells with inhibition of proliferation and invasion in vitro as well as EN2 knockdown decreased the tumor growth of BC. 25812440 2015
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 Biomarker disease BEFREE EN2 knockdown significantly promoted cell cycle arrest and apoptosis of BC cells with inhibition of proliferation and invasion in vitro as well as EN2 knockdown decreased the tumor growth of BC. 25812440 2015
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.010 Biomarker disease BEFREE EN2 knockdown significantly promoted cell cycle arrest and apoptosis of BC cells with inhibition of proliferation and invasion in vitro as well as EN2 knockdown decreased the tumor growth of BC. 25812440 2015
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.010 Biomarker disease BEFREE Lineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T-cell blast crisis. 24675889 2014