|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo experiments certified that circ-ENO1 drove tumor growth and metastasis in vivo.
|
31767835 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although promising, the ENO1 DNA vaccine does not completely eradicate the tumor, which, after an initial growth inhibition, returns to proliferate again, especially when Tregs and MDSC ensue in the tumor mass.
|
29462900 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, ENO1 241-260cit<sub>253</sub> induced therapy of pancreatic (Pan02-DR4 50% survival <i>p</i> = 0.0076) and lung (LLC/2-DR4 40% survival <i>p</i> = 0.0142) tumors in HLA-DR4 transgenic mice.
|
29308319 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ENO1 plays a paradoxical role in driving the pathogenesis of tumors.
|
25951350 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although several lines of evidence indicate that MBP-1 acts as a tumor suppressor, the cellular mechanisms and signaling pathways underlying MBP-1 expression still remain largely elusive.
|
26144282 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evidence is presented linking biotinylation of heat-shock proteins HSP60 and HSP72 with redox biology and immune function, respectively, and biotinylation of the two ENO1 gene products MBP-1 and ENO1 with tumor suppression and glycolysis, respectively.
|
24684412 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis.
|
23975832 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Altogether, our in vitro and in vivo data indicate that the ERBB2 gene is a novel MBP-1 target, and immunohistochemistry analysis of primary tumors suggests that the concomitant high expression of MBP-1 and HDAC1 may be considered a diagnostic marker of cancer progression for breast IDC.
|
23421821 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
About 75% of patients with CCA showed over-expression of ENO1 in hyperplastic bile duct and the tumors compared with that in tumor-adjacent normal tissue counterparts.
|
22552009 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The proteins, which might be involved in the development of tumor drug resistance, such as α-enolase, cofilin, and thioredoxin-dependent peroxide 1, have been validated by western blot analysis and have been discussed.
|
21637159 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
α-Enolase: a promising therapeutic and diagnostic tumor target.
|
21261815 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ectopic ENO1 expression stimulated cell transformation, invasion and tongue tumour formation.
|
20435467 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistically significant associations were observed among the nuclear expression of MBP-1 and ErbB2 status, Ki-67 expression, node status and tumor grade.
|
20886042 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, we suggest that this newly discovered transcript is a genuine template for the protein synthesis of MBP-1 in cells, and optimal expression of this gene in tumors may lead to effective clinical therapies for cancers.
|
20849415 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results demonstrate that malignant cells adapt to hypoxia by modulating alpha-enolase/MBP-1 levels and suggest a mechanism for tumor cell induction of the hyperglycolytic state.
|
20412594 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These effects could also be shown in non-neuroblastoma cells (293-cells), indicating ENO1 to have general tumour suppressor activity.
|
16359544 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest the possible involvement of MBP-1 as a tumor suppressor gene in human breast carcinoma cells.
|
7641187 |
1995 |