|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Poor response to treatment associated significantly with the expression of neuron specific enolase (NSE), β-catenin and PHOX2B in NB patients (P = .021, P = .019 and P = .040; respectively).
|
31220430 |
2019 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The plasma cfDNA concentration was as good as the levels of LDH and NSE to discriminate the tumor burden in children with NB.
|
29905010 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both CgA and NSE correlated to genetic markers, while only NSE correlated to primary tumor size and outcome in NB.
|
29737901 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We retrospectively reviewed the pretreatment clinical (age, sex and tumor stage) and biological (MYCN amplification; and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of 279 patients who were diagnosed with pathologically confirmed NB and GNB from January 2005 to December 2015.
|
28465480 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analyses of the molecular role of tissue-nonspecific alkaline phosphatase (TNAP) in transgenic SH-SY5Y(TNAPhigh) neuroblastoma cells compared to SH-SY5Y(TNAPlow) cells indicate that the enzyme influences the expression levels of neuronal marker genes like RNA-binding protein, fox-1 homolog 3 (NEUN) and enolase 2, gamma neuronal (NSE) as well as microtubule-binding proteins like microtubule-associated protein 2 (MAP2) and microtubule-associated protein tau (TAU) during neurogenic differentiation.
|
26032516 |
2015 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, NSE determination in cord blood offers an early postnatal possibility of confirming the diagnosis of neuroblastoma in newborns.NSE has been demonstrated to provide quantitative measures of brain damage and/or to improve the diagnosis and the outcome evaluation in ischaemic stroke, intracerebral hemorrhage, seizures, comatose patients after cardiopulmonary resuscitation for cardiac arrest and traumatic brain injury.Increased NSE serum levels have also been found associated with melanoma, seminoma, renal cell carcinoma, Merkel cell tumour, carcinoid tumours, dysgerminomas and immature teratomas, malignant phaechromocytoma, Guillain-Barré syndrome and Creutzfeldt-Jakob disease.
|
26530364 |
2015 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reporter gene expression by NSEp in neuroblastoma cells was markedly higher than expression by THp, but NSEp also showed considerable background activity in nonneuronal cells.
|
15181182 |
2004 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nonmyogenic markers included: vimentin (100%), CD99 (16%), p53 (16%), pancytokeratin (10%), NSE (8%), LCA (6%), CD20 (6%), EMA (2%), and NB-84 (0%, neuroblastoma).
|
12110339 |
2002 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neuron-specific enolase (NSE) was negative in 3 and positive in 8 cases of neuroblastoma, whereas neuroblastoma marker was positive in 3/11.
|
11285617 |
2001 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, NSE positivity can be a pitfall for a diagnosis of neuroblastoma if the radiologic, clinical, and other cytologic features are not clearly delineated.
|
8964164 |
1996 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The immunohistochemical stains showed positivity for neuron-specific enolase in the cells comprising the neuroblastoma, and transmission electron microscopic study corroborated these findings by demonstrating microtubules and rare membrane-limited, dense-core granules in the cytoplasm.
|
8242553 |
1993 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Six independent clonal isolates from a morphologically heterogeneous human neuroblastoma cell line stably expressed several products of the human amyloid precursor protein (APP) from an introduced DNA construct; the "substrate-adherent" phenotype (fibroblast-like cells) predominated in all 6; these displayed immunoreactivity of vimentin, but little to no reactivity of neuron-specific enolase.
|
1334198 |
1992 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-myc gene amplification of the gynecological malignant tumor cell lines and a neuroblastoma cell line was studied by the Southern hybridization method along with the production of neuron-specific enolase (NSE) by these cell lines.
|
2542141 |
1989 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Four neuroblastoma (LA-N-5, SH-SY5Y, Paju, and SK-N-MC) and three small-cell lung carcinoma (U-2020, U-1690, and U-1285) cell lines were selected on the basis of their stage of neurocrine differentiation, as determined by the expression of neuron-specific enolase.
|
2830484 |
1987 |