TUBB, tubulin beta class I, 203068

N. diseases: 96; N. variants: 7
Disease: Adenocarcinoma of lung (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE We found that miR-195 directly targets <i>TUBB</i>; knockdown of <i>TUBB</i> sensitizes cells to MTAs, while overexpression confers resistance; high expression of <i>TUBB</i> is correlated with worse survival of lung adenocarcinoma; TUBB is also regulated by CHEK1, which has been shown to regulate chemoresistance; and miR-195 targets <i>BIRC5</i> to repress migration and invasion <i>in vitro</i> and metastasis <i>in vivo</i>. 31508486 2019