PRSS55, serine protease 55, 203074

N. diseases: 163; N. variants: 0
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE Its ligand, thromobospondin-1 (TSP-1) is a multifunctional protein, and CD47/TSP-1 interactions promote tumor progression in various malignancies. 31712778 2020
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE Dysregulation of Rab37/TSP1 axis has clinical implications for prognosis prediction.<i>Clin Cancer Res; 23(9); 2335-45.©2016 AACR</i>. 28151721 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE In addition, special attention is paid to TSP-1-derived peptide and TSP-1-based therapy for malignancies. 23749112 2013
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 PosttranslationalModification group BEFREE TSP1 is methylated in several malignancies, and can inhibit angiogenesis in melanoma xenografts. 23202046 2013
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 GeneticVariation group BEFREE Transcriptional repressor Id1 is overexpressed in many malignancies including melanoma, and Id1 targets include tumor suppressor genes TSP1, CDKN2A (p16) and CDKN1A (p21), which are frequently epigenetically silenced in cancer. 20484992 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE Furthermore, we provide evidence that the loss of a copy of chromosome 15 is responsible for reduced TSP-1 expression and thereby this aberration contributes to tumour vascularisation (i.e. the angiogenic switch) required for malignant growth. 17198740 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE TSP-1 immunoreactivity was detected in the cancer stroma. 12429967 2002