Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present work was to investigate the association between the Y113H polymorphism (rs1051740) in EPHX1 gene and -308G/A polymorphism (rs1800629) in TNF-a gene and COPD in Kazakhstan population.
|
28464990 |
2017 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found no association between EPHX1 and COPD; however, a minor effect of EPHX1 on COPD risk was not completely excluded; further replication studies with large samples are needed to confirm our findings.
|
27173271 |
2016 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
A total of 219 patients with COPD were randomly allocated to an extremely slow/slow EPHX1 enzyme activity group (n=157) or a fast/normal EPHX1 enzyme activity group (n=62) according to their EPHX1 enzyme activity.
|
25999707 |
2015 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As expected, wild homozygotes for GSTP1 Ile105Val and EPHX1 slow/very slow phenotypes were associated with susceptibility (P=0.031) and severity (P=0.036) of COPD, respectively.
|
21651746 |
2013 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subjects with EPHX1 113 (His(113)/His(113)) homozygote mutation had a strong correlation with COPD (odds ratio: 2.7, 95% confidence interval: 1.5-5.2).
|
22118311 |
2011 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combination of 113His/His EPHX1/null-GSTM1 genotypes showed a significant association with the decrease of Δ FEV1 in patients (P =0.028).In conclusion, our results suggest combined EPHX1, GSTP1, GSTM1 and GSTT1 genetic polymorphisms may play a significant role in the development of COPD, emphysema and decline of the lung function.
|
21734345 |
2011 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that genetically reduced microsomal epoxide hydrolase activity is not a major risk factor for COPD or asthma in the Danish population; however, meta-analysis cannot completely exclude a minor effect on COPD risk.
|
20516053 |
2011 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, combined genetic polymorphisms of GSTM1, GSTT1, GSTP1, and EPHX1 may have favorable effects on redox balance in COPD patients.
|
21309732 |
2011 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consequently, heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), microsomal epoxide hydrolase (EPHX1), and cytochrome P450 (CYP) genetic polymorphisms may have an important role in COPD pathogenesis.
|
21721950 |
2011 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An increased risk for COPD was observed in subjects with EPHX1 His113-His113 genotype (odds ratio = 2.168; confidence interval 1.098-4.283; p = 0.02386).
|
20932192 |
2010 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study.
|
21044285 |
2010 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association of variation was found in EPHX1 or GCL with susceptibility to COPD or disease severity.
|
18614560 |
2008 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although none of the tested gene polymorphisms was significantly related to an increased risk of COPD alone, our results suggest that the homozygous exon 3 mutant variant of EPHX1 gene in the combination with GSTM1 null genotype is a significant predictor of increased susceptibility to COPD in the Slovak population.
|
18461673 |
2008 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Although none of the tested gene polymorphisms was significantly related to an increased risk of COPD alone, our results suggest that the homozygous exon 3 mutant variant of EPHX1 gene in the combination with GSTM1 null genotype is a significant predictor of increased susceptibility to COPD in the Slovak population.
|
18461673 |
2008 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in HOX-1 and mEPH genes are associated with the development of COPD in Southwest China.
|
17203192 |
2007 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the 42 studied candidate genes, the expressions of mRNA for catalase, glutathion S-transferase P1 (GSTP1), glutathion S-transferase M1 (GSTM1), microsomal epoxide hydrolase (mEPHX) and tissue inhibitor of metalloproteinase 2 (TIMP2) were significantly decreased in COPD lung tissues compared with those in non-COPD tissues, and most of these decreases were significantly correlated with the degree of airflow limitation.
|
16919984 |
2007 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In a case-control analysis of COPD susceptibility limited to cases with densitometric upper-lobe-predominant cases, the EPHX1 His139Arg single-nucleotide polymorphism was associated with COPD (p = 0.005).
|
17363767 |
2007 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a case-control analysis of COPD susceptibility limited to cases with densitometric upper-lobe-predominant cases, the EPHX1 His139Arg single-nucleotide polymorphism was associated with COPD (p = 0.005).
|
17363767 |
2007 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In addition, none of the EPHX1 haplotypes were associated with an increased risk of any COPD phenotype.
|
17564249 |
2006 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, none of the EPHX1 haplotypes were associated with an increased risk of any COPD phenotype.
|
17564249 |
2006 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The test-replication approach identified four genes-microsomal epoxide hydrolase (EPHX1), latent transforming growth factor-beta binding protein-4 (LTBP4), surfactant protein B (SFTPB), and transforming growth factor-beta1 (TGFB1)-that were associated with COPD-related phenotypes.
|
16456143 |
2006 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD.
|
15702235 |
2005 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD.
|
15702235 |
2005 |
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is proposed that the combination of genetic variants including at least one mutant microsomal epoxide hydrolase exon-3 allele and glutathione S-transferase M1-null and homozygous isoleucine 105 glutathione S-transferase P1 genotypes are significant indicators of susceptibility to chronic obstructive pulmonary disease in the Taiwanese population.
|
15218992 |
2004 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The proportion of mEH exon 3 heterozygotes was significantly higher in patients with COPD than that in the control subjects (42% vs 32%).
|
15161530 |
2004 |