Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Taken together, ERBB2 is required for the dysregulation of cancer-related genes, such as <i>MED24</i>, during lung tumor development.
|
31248101 |
2019 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Almost four-fifths of the lung tumors with MET exon 14 skipping had EGFR and/or HER2 gene copy number gains.
|
27223439 |
2016 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Despite the assay used to determine the HER2 status of lung tumors, all patients with advanced HER2 positive lung adenocarcinoma should be evaluated for treatment with targeted agents.
|
25601485 |
2015 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Typical HER2 downstream signaling mediators, including PLCγ1, STAT5 and AKT, were hyperactivated in HER2H878Y driven lung tumors.
|
26375550 |
2015 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib.
|
25249545 |
2014 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin.
|
18078328 |
2008 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These results provide a rationale for treatment of patients with ERBB2-mutant or ERBB2-amplified lung tumors with HKI-272.
|
17311002 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.
|
18089823 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients.
|
17321325 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
|
17575133 |
2007 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The aim of the study was to investigate a relation between p53 and HER2/neu expression in resected lung tumors and the response of those tumors to neoadjuvant chemotherapy.
|
16847810 |
2006 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features.
|
16988931 |
2006 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma.
|
16959370 |
2006 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We sequenced the tyrosine kinase domain of HER2 in 671 primary non-small cell lung cancers (NSCLC), 80 NSCLC cell lines, and 55 SCLCs and other neuroendocrine lung tumors as well as 85 other epithelial cancers (breast, bladder, prostate, and colorectal cancers) and compared the mutational status with clinicopathologic features and the presence of EGFR or KRAS mutations.
|
15753357 |
2005 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations.
|
15457249 |
2004 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer.
|
14734462 |
2004 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Effects of gefitinib on serum epidermal growth factor receptor and HER2 in patients with advanced non-small cell lung cancer.
|
15447984 |
2004 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
[Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer].
|
14761474 |
2003 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer.
|
14566828 |
2003 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.
|
12483526 |
2002 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.
|
12483526 |
2002 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, there was a highly significant correlation between the c-erbB2 expression comparing the whole section immunostaining analysis and a 127 lung tumour tissue array which included 74 of the 89 cases that were analysed by the classical procedure.
|
11378338 |
2001 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
There was, in general, an excellent concordance between the lung tumor cell lines and their corresponding tumor tissues for morphology (100%), the presence of aneuploidy (100%), immunohistochemical expression of HER2/neu (100%) and p53 proteins (100%), loss of heterozygosity at 13 chromosomal regions analyzed (97%) using 37 microsatellite markers, microsatellite alterations (MAs, 75%), TP53 (67%), and K-ras (100%) gene mutations.
|
10353731 |
1999 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The 201T cell line was isolated recently from a lung tumor with erbB-2 expression in the original tumor.
|
9816093 |
1996 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
On average, all the tumor cell lines showed 2-fold expression of c-myc compared with the lung tumors (P less than 0.025). c-erbB-2 expression was found in six of 11 cell lines.
|
1355655 |
1992 |