ERBB3, erb-b2 receptor tyrosine kinase 3, 2065

N. diseases: 318; N. variants: 16
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE CACNA1D, GNAO1, STAT3 and ERBB3 might serve as the prognostic biomarkers in glioblastoma. 31567312 2020
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE Collectively, these findings show that GBM therapeutic resistance to EGFR inhibitors may be explained by compensatory activation of EGFR-related family members (ERBB2, ERBB3) enabling GBM CSC proliferation, and therefore simultaneous blockade of multiple ERBB family members may be required for more efficacious GBM therapy. 22745588 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. 21439954 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 AlteredExpression disease BEFREE Differential distribution of erbB receptors in human glioblastoma multiforme: expression of erbB3 in CD133-positive putative cancer stem cells. 20467331 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 AlteredExpression disease BEFREE Using gene expression microarray and Western blot analyses, we found that ErbB3 is highly overexpressed in PA compared with other pediatric brain tumors (glioblastoma, ependymoma, medulloblastoma, atypical teratoid/rhabdoid tumor, and choroid plexus papilloma). 16896310 2006