|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, there were no significant differences of the ERCC1 or XPF mRNA and/or protein expression levels between males and females(P > 0.05).
|
28486142 |
2017 |
|
Xeroderma pigmentosum, group F
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ERCC1 point mutation F231L, located at the hydrophobic interaction interface of ERCC1 (excision repair cross-complementation group 1) and XPF (xeroderma pigmentosum complementation group F), leads to severe NER pathway deficiencies.
|
26085086 |
2015 |
|
Xeroderma pigmentosum, group F
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use.
|
24861646 |
2014 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we found that loss of the structure-specific endonuclease ERCC1-XPF (ERCC4) is synthetic lethal with ATR pathway inhibitors.
|
24662920 |
2014 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, in particular cell models of the interaction between ERCC1 and XPF, DNA repair was decreased, as evidenced by increased phosphorylation of the histone 2AX after exposure to mitomycin C, and genomic instability was increased, as determined by comparative genomic hybridization studies.
|
25115435 |
2014 |
|
Xeroderma pigmentosum, group F
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we found that ERCC1 rs11615 and XPF rs2276465 may substantially contribute to the future design of individualized cancer treatment in gastric cancer patients.
|
24793015 |
2014 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, gastric cancer cell lines were transfected with mutated XPF to explore XPF/ERCC1 interaction, XPF degradation, and DNA repair by a comet assay.
|
24412486 |
2014 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further large-scale studies are required to elucidate whether these ERCC1 and XPF SNPs interact with environmental factors in the development of breast cancer.
|
23909490 |
2013 |
|
Xeroderma pigmentosum, group F
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.
|
20221251 |
2010 |
|
Xeroderma pigmentosum, group F
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Saccharomyces cerevisiae, orthologs of ERCC1-XPF (Rad10-Rad1) participate in the repair of double-strand breaks (DSBs).
|
18541667 |
2008 |
|
Xeroderma pigmentosum, group F
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sensitivity of group F xeroderma pigmentosum cells to UV and mitomycin C relative to levels of XPF and ERCC1 overexpression.
|
9862190 |
1998 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests that the ERCC1-dependent step in cross-link repair occurs outside the context of NER and provides an explanation for the phenotype of the human repair syndrome xeroderma pigmentosum group F.
|
8811092 |
1996 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.
|
8253091 |
1993 |
|
Xeroderma pigmentosum, group F
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data suggest that ERCC1 is part of a functional protein complex with group 4 and XP-F correcting activities.
|
8253090 |
1993 |